Nucleus implant parameters significantly change the compressive stiffness of the human lumbar intervertebral disc

Abhijeet Joshi; Samir Mehta; Edward Vresilovic; Andrew Karduna; Michele Marcolongo

doi:10.1115/1.1894369

Nucleus implant parameters significantly change the compressive stiffness of the human lumbar intervertebral disc

Abhijeet Joshi, Samir Mehta, Edward Vresilovic, Andrew Karduna, Michele Marcolongo

Department of Orthopaedics and Rehabilitation

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

Nucleus replacement by a synthetic material is a recent trend for treatment of lower back pain. Hydrogel nucleus implants were prepared with variations in implant modulus, height, and diameter. Human lumbar intervertebral discs (IVDs) were tested in compression for intact, denucleated, and implanted condition. Implantation of nucleus implants with different material and geometric parameters into a denucleated IVD significantly altered the IVD compressive stiffness. Variations in the nucleus implant parameters significantly change the compressive stiffness of the human lumbar IVD. Implant geometrical variations were more effective than those of implant modulus variations in the range examined.

Original language	English (US)
Pages (from-to)	536-540
Number of pages	5
Journal	Journal of Biomechanical Engineering
Volume	127
Issue number	3
DOIs	https://doi.org/10.1115/1.1894369
State	Published - Jun 2005

All Science Journal Classification (ASJC) codes

Biomedical Engineering
Physiology (medical)

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abstract = "Nucleus replacement by a synthetic material is a recent trend for treatment of lower back pain. Hydrogel nucleus implants were prepared with variations in implant modulus, height, and diameter. Human lumbar intervertebral discs (IVDs) were tested in compression for intact, denucleated, and implanted condition. Implantation of nucleus implants with different material and geometric parameters into a denucleated IVD significantly altered the IVD compressive stiffness. Variations in the nucleus implant parameters significantly change the compressive stiffness of the human lumbar IVD. Implant geometrical variations were more effective than those of implant modulus variations in the range examined.",

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AU - Marcolongo, Michele

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AB - Nucleus replacement by a synthetic material is a recent trend for treatment of lower back pain. Hydrogel nucleus implants were prepared with variations in implant modulus, height, and diameter. Human lumbar intervertebral discs (IVDs) were tested in compression for intact, denucleated, and implanted condition. Implantation of nucleus implants with different material and geometric parameters into a denucleated IVD significantly altered the IVD compressive stiffness. Variations in the nucleus implant parameters significantly change the compressive stiffness of the human lumbar IVD. Implant geometrical variations were more effective than those of implant modulus variations in the range examined.

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Nucleus implant parameters significantly change the compressive stiffness of the human lumbar intervertebral disc

Abstract

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