TY - JOUR
T1 - Number of natural teeth, denture use and mortality in Chinese elderly
T2 - A population-based prospective cohort study
AU - Yuan, Jin Qiu
AU - Lv, Yue Bin
AU - Kraus, Virginia Byers
AU - Gao, Xiang
AU - Yin, Zhao Xue
AU - Chen, Hua Shuai
AU - Luo, Jie Si
AU - Zeng, Yi
AU - Mao, Chen
AU - Shi, Xiao Ming
N1 - Funding Information:
This work was supported by the Startup Fund for the 100 Top Talents Program, SYSU [grant number 392012], the National Natural Sciences Foundation of China [grant numbers 71233001, 71490732 and 81573247], the U.S. National Institute of Aging / United Nations Fund for Population Activities [grant number 2P01AG031719], and Claude D. Pepper Older Americans Independence Centers grant [grant number 5P30 AG028716]. The funders of the study had no role in study design, data analysis, data interpretation, or writing of the report. The corresponding authors had full access to all the data in the study and had the final responsibility to submit for publication.
Publisher Copyright:
© 2020 The Author(s).
PY - 2020/4/10
Y1 - 2020/4/10
N2 - Background: The associations between the number of natural teeth/denture use and all-cause mortality remain unclear due to lake of investigation for the potential interaction between tooth loss and denture use and for the potential changes in these exposures over time in older adults. We undertake this study to evaluate the associations of the number of natural teeth and/or denture use with mortality in Chinese elderly. Methods: This is a prospective cohort study of 36,283 older adults (median age: 90). The number of natural teeth and denture use were collected with structured questionnaire. We evaluated hazard ratios (HRs) and confidence intervals (CIs) using a Cox proportional hazards model adjusting for demographic factors, education, income, lifestyle factors, and comorbidities. Results: We documented 25,857 deaths during 145,947 person-years of observation. Compared to those with 20+ teeth, tooth loss was associated with a gradual increase in mortality, with an adjusted HR of 1.14 (95% CI, 1.06 to 1.23) for those with 10-19 teeth, 1.23 (95% CI, 1.15 to 1.31) for those with 1-9 teeth, and 1.35 (95% CI, 1.26 to 1.44) for those without natural teeth. Denture use was associated with lower risk of mortality (adjusted HR 0.81; 95% CI, 0.77 to 0.84). Subgroup analyses indicated that the benefit of denture use was greater in men than in women (P = 0.02) and tended to decrease with age (P < 0.001). The effects of denture use did not differ among various degrees of tooth loss (P = 0.17). Conclusions: Tooth loss was associated with an increased risk of mortality in older adults. Denture use provided a protective effect against death for all degrees of tooth loss however, this effect appeared to be modified by sex and age.
AB - Background: The associations between the number of natural teeth/denture use and all-cause mortality remain unclear due to lake of investigation for the potential interaction between tooth loss and denture use and for the potential changes in these exposures over time in older adults. We undertake this study to evaluate the associations of the number of natural teeth and/or denture use with mortality in Chinese elderly. Methods: This is a prospective cohort study of 36,283 older adults (median age: 90). The number of natural teeth and denture use were collected with structured questionnaire. We evaluated hazard ratios (HRs) and confidence intervals (CIs) using a Cox proportional hazards model adjusting for demographic factors, education, income, lifestyle factors, and comorbidities. Results: We documented 25,857 deaths during 145,947 person-years of observation. Compared to those with 20+ teeth, tooth loss was associated with a gradual increase in mortality, with an adjusted HR of 1.14 (95% CI, 1.06 to 1.23) for those with 10-19 teeth, 1.23 (95% CI, 1.15 to 1.31) for those with 1-9 teeth, and 1.35 (95% CI, 1.26 to 1.44) for those without natural teeth. Denture use was associated with lower risk of mortality (adjusted HR 0.81; 95% CI, 0.77 to 0.84). Subgroup analyses indicated that the benefit of denture use was greater in men than in women (P = 0.02) and tended to decrease with age (P < 0.001). The effects of denture use did not differ among various degrees of tooth loss (P = 0.17). Conclusions: Tooth loss was associated with an increased risk of mortality in older adults. Denture use provided a protective effect against death for all degrees of tooth loss however, this effect appeared to be modified by sex and age.
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U2 - 10.1186/s12903-020-01084-9
DO - 10.1186/s12903-020-01084-9
M3 - Article
C2 - 32276615
AN - SCOPUS:85083286146
SN - 1472-6831
VL - 20
JO - BMC Oral Health
JF - BMC Oral Health
IS - 1
M1 - 100
ER -