TY - JOUR
T1 - Nutrigenomics, the microbiome, and gene-environment interactions
T2 - New directions in cardiovascular disease research, prevention, and treatment
AU - Ferguson, Jane F.
AU - Allayee, Hooman
AU - Gerszten, Robert E.
AU - Ideraabdullah, Folami
AU - Kris-Etherton, Penny M.
AU - Ordovás, José M.
AU - Rimm, Eric B.
AU - Wang, Thomas J.
AU - Bennett, Brian J.
N1 - Publisher Copyright:
© 2016 American Heart Association, Inc.
PY - 2016/6/1
Y1 - 2016/6/1
N2 - Cardiometabolic diseases are the leading cause of death worldwide and are strongly linked to both genetic and nutritional factors. The field of nutrigenomics encompasses multiple approaches aimed at understanding the effects of diet on health or disease development, including nutrigenetic studies investigating the relationship between genetic variants and diet in modulating cardiometabolic risk, as well as the effects of dietary components on multiple "omic" measures, including transcriptomics, metabolomics, proteomics, lipidomics, epigenetic modifications, and the microbiome. Here, we describe the current state of the field of nutrigenomics with respect to cardiometabolic disease research and outline a direction for the integration of multiple omics techniques in future nutrigenomic studies aimed at understanding mechanisms and developing new therapeutic options for cardiometabolic disease treatment and prevention.
AB - Cardiometabolic diseases are the leading cause of death worldwide and are strongly linked to both genetic and nutritional factors. The field of nutrigenomics encompasses multiple approaches aimed at understanding the effects of diet on health or disease development, including nutrigenetic studies investigating the relationship between genetic variants and diet in modulating cardiometabolic risk, as well as the effects of dietary components on multiple "omic" measures, including transcriptomics, metabolomics, proteomics, lipidomics, epigenetic modifications, and the microbiome. Here, we describe the current state of the field of nutrigenomics with respect to cardiometabolic disease research and outline a direction for the integration of multiple omics techniques in future nutrigenomic studies aimed at understanding mechanisms and developing new therapeutic options for cardiometabolic disease treatment and prevention.
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U2 - 10.1161/HCG.0000000000000030
DO - 10.1161/HCG.0000000000000030
M3 - Article
C2 - 27095829
AN - SCOPUS:84975726343
SN - 1942-325X
VL - 9
SP - 291
EP - 313
JO - Circulation: Cardiovascular Genetics
JF - Circulation: Cardiovascular Genetics
IS - 3
ER -