Nutritional control of HIV-AIDS- A case for selenium

Parisa Kalantari, Hema Vunta, Umamaheswari D. Palempalli, C. Channa Reddy, Andrew J. Henderson, K. Sandeep Prabhu

Research output: Contribution to journalShort surveypeer-review


Selenium (Se) is a micronutrient that is incorporated into proteins. Some of the selenoenzymes such as GPXs and thioredoxin reductases exhibit glutathione peroxidase-dependent activities towards organic and inorganic peroxides. Thus, selenoenzymes play a pivotal role in mitigating oxidative stress caused by accumulation of peroxides. In this respect, selenoproteins may interfere with the transcription-driven by oxidative stress-dependent signaling mechanisms to influence the expression of redox sensitive genes, including inflammatory cytokines and HIV provirus. Several epidemiological studies support our view that Se supplementation affects transcription of HIV; however, the underlying mechanism is not elucidated. In this mini review, we ccnsider the relationship between Se and HIV and propose possible mechanisms by which Se controls HIV transcription.

Original languageEnglish (US)
Pages (from-to)195-201
Number of pages7
JournalAmerican Journal of Infectious Diseases
Issue number4
StatePublished - 2007

All Science Journal Classification (ASJC) codes

  • Infectious Diseases


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