Nutritionally complete prepared meal plan to reduce cardiovascular risk factors: A randomized clinical trial

R. Brian Haynes, Penny Kris-Etherton, David A. McCarron, Suzanne Oparil, Alan Chait, Lawrence M. Resnick, Cynthia D. Morris, Sharon Clark, Daniel C. Hatton, Jill A. Metz, Margaret McMahon, Scott Holcomb, Geoffrey W. Snyder, F. Xavier Pi-Sunyer, Judith S. Stern

Research output: Contribution to journalArticlepeer-review

29 Scopus citations


Objective: To compare a nutritionally complete prepared meal plan that meets national dietary guidelines to usual-care dietary therapy for hypertension, dyslipidemia, and glycemic control. Design: Randomized, controlled trial. Subjects/setting: Outpatients with hypertension, dyslipidemia, or diabetes mellitus (n=251) were recruited at 6 medical centers in the United States and Canada. Intervention: The prepared meal plan, which was developed by university-based nutrition and cardiovascular scientists and food technologists at Campbell's Center for Nutrition and Wellness (CCNW), provided the optimal levels of macronutrients and micronutrients recommended for cardiovascular risk reduction in a variety of prepackaged meals and snacks. After a 4-week pretrial period to assess baseline state, participants were randomized to the CCNW plan or 'usual-care' diet for 10 weeks. Main outcome measures: Blood pressure, carbohydrate metabolism, lipoproteins, homocysteine, weight, nutrient intake, compliance. Statistical analyses performed: Repeated measures analysis of variance. Results: Lipoproteins, carbohydrate metabolism, blood pressure, and weight improved on both plans. Mean differences (±standard deviation) between baseline and follow-up for the CCNW plan and the usual-care plan, respectively, were total cholesterol, -0.41±0.64 and -0.20±0.50 mmol/L (between-group P<.01); plasma glucose, -0.7±1.7 and -0.3±1.3 mmol/L (P<.05); systolic blood pressure, -5.2±10.0 and -4.7±9.0 mm Hg (P=.67), diastolic blood pressure, -3.8±5.9 and -2.2±5.5 mm Hg (P<.05); and homocysteine, -1.3±3.8 and 0.2±3.4 μmol/L (P<.01). The CCNW plan led to greater weight loss than the usual-care diet (-5.5±3.8 kg vs -3.0±3.2 kg, P<.0001). Applications/conclusion: The nutritionally complete CCNW plan offers greater improvements in lipids, blood sugars, homocysteine, and weight loss than usual-care diet therapy. This prepackaged comprehensive nutrition program can augment both the prescription and practice of optimal dietary therapy.

Original languageEnglish (US)
Pages (from-to)1077-1083
Number of pages7
JournalJournal of the American Dietetic Association
Issue number9
StatePublished - Sep 1999

All Science Journal Classification (ASJC) codes

  • Food Science
  • Nutrition and Dietetics


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