OARSI Clinical Trials Recommendations: Knee imaging in clinical trials inosteoarthritis

D. J. Hunter, R. D. Altman, F. Cicuttini, M. D. Crema, J. Duryea, F. Eckstein, A. Guermazi, R. Kijowski, T. M. Link, J. Martel-Pelletier, C. G. Miller, T. J. Mosher, R. E. Ochoa-Albíztegui, J. P. Pelletier, C. Peterfy, J. P. Raynauld, F. W. Roemer, S. M. Totterman, G. E. Gold

Research output: Contribution to journalReview articlepeer-review

110 Scopus citations


Significant advances have occurred in our understanding of the pathogenesis of knee osteoarthritis (OA) and some recent trials have demonstrated the potential for modification of the disease course. The purpose of this expert opinion, consensus driven exercise is to provide detail on how one might use and apply knee imaging in knee OA trials. It includes information on acquisition methods/techniques (including guidance on positioning for radiography, sequence/protocol recommendations/hardware for magnetic resonance imaging (MRI)); commonly encountered problems (including positioning, hardware and coil failures, sequences artifacts); quality assurance (QA)/control procedures; measurement methods; measurement performance (reliability, responsiveness, validity); recommendations for trials; and research recommendations.

Original languageEnglish (US)
Pages (from-to)698-715
Number of pages18
JournalOsteoarthritis and Cartilage
Issue number5
StatePublished - 2015

All Science Journal Classification (ASJC) codes

  • Rheumatology
  • Biomedical Engineering
  • Orthopedics and Sports Medicine


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