2 Scopus citations


We describe our ongoing efforts to understand the dynamics of the sleep-wake regulatory system to improve seizure prediction. Although mathematical models of its dynamics have been developed, the activity of this system is difficult to observe directly. Therefore we have developed a data assimilation framework that combines sparse measurements of the sleep-wake regulatory system together with a mathematical model of its dynamics to estimate the unmeasured variables. This toolset will allow us to understand the interaction between modulators of the state-of-vigilance and seizure susceptibility and may provide meaningful indicators of an impending seizure.

Original languageEnglish (US)
Title of host publicationRecent Advance in Predicting and Preventing Epileptic Sezures
PublisherWorld Scientific Publishing Co.
Number of pages14
ISBN (Electronic)9789814525350
ISBN (Print)9789814525343
StatePublished - Jan 1 2013

All Science Journal Classification (ASJC) codes

  • General Computer Science
  • General Medicine
  • General Neuroscience


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