TY - JOUR
T1 - Obstructive sleep apnea and blood pressure elevation
T2 - What is the relationship?
AU - Jan, Carlson
AU - Robert, Davies
AU - Klaus, Ehlenz
AU - Ron, Grunstein
AU - Jan, Hedner
AU - Thomas, Podszus
AU - Lawrence, Sinoway
AU - John, Stradling
AU - Tiina, Telakivi
AU - Clifford, Zwillich
PY - 1993
Y1 - 1993
N2 - Sleep disordered breathing has increasingly been recognised as a frequent cause of ill-health in the community. Moderate or severe forms of the most common condition, obstructive sleep apnea (OSA), occur in up to 12% of the adult male population. A substantial body of literature has been published on the potential relationship between OSA and cardiovascular disease. In particular, OSA has been associated with cardiac failure, stroke, myocardial infarction and hypertension. Part of this association may be explained by other confounders, mainly obesity, which is common in OSA patients. The present review was prepared following a workshop aimed to critically review available scientific evidence suggesting that hypertension is a direct consequence of OSA. In addition, pathophysiologic mechanisms that may be involved in the relationship between OSA and cardiovascular disease, particularly brief intermittent elevation of blood pressure and sustained systemic hypertension, are discussed.
AB - Sleep disordered breathing has increasingly been recognised as a frequent cause of ill-health in the community. Moderate or severe forms of the most common condition, obstructive sleep apnea (OSA), occur in up to 12% of the adult male population. A substantial body of literature has been published on the potential relationship between OSA and cardiovascular disease. In particular, OSA has been associated with cardiac failure, stroke, myocardial infarction and hypertension. Part of this association may be explained by other confounders, mainly obesity, which is common in OSA patients. The present review was prepared following a workshop aimed to critically review available scientific evidence suggesting that hypertension is a direct consequence of OSA. In addition, pathophysiologic mechanisms that may be involved in the relationship between OSA and cardiovascular disease, particularly brief intermittent elevation of blood pressure and sustained systemic hypertension, are discussed.
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U2 - 10.3109/08037059309077548
DO - 10.3109/08037059309077548
M3 - Comment/debate
C2 - 8205310
AN - SCOPUS:0027491803
SN - 0803-7051
VL - 2
SP - 166
EP - 182
JO - Blood Pressure
JF - Blood Pressure
IS - 3
ER -