TY - JOUR
T1 - Obstructive sleep apnea
T2 - The new cardiovascular disease. Part I: Obstructive sleep apnea and the pathogenesis of vascular disease
AU - Khayat, Rami
AU - Patt, Brian
AU - Hayes, Don
PY - 2009
Y1 - 2009
N2 - Obstructive sleep apnea (OSA) is increasingly recognized as a novel cardiovascular risk factor. OSA is implicated in the pathogenesis of hypertension, left ventricular dysfunction, coronary artery disease and stroke. OSA exerts its negative cardiovascular consequences through its unique pattern of intermittent hypoxia. Endothelial dysfunction, oxidative stress, and inflammation are all consequences of OSA directly linked to intermittent hypoxia and critical pathways in the pathogenesis of cardiovascular disease in patients with OSA. This review will discuss the known mechanisms of vascular dysfunction in patients with OSA and their implications for cardiovascular disease.
AB - Obstructive sleep apnea (OSA) is increasingly recognized as a novel cardiovascular risk factor. OSA is implicated in the pathogenesis of hypertension, left ventricular dysfunction, coronary artery disease and stroke. OSA exerts its negative cardiovascular consequences through its unique pattern of intermittent hypoxia. Endothelial dysfunction, oxidative stress, and inflammation are all consequences of OSA directly linked to intermittent hypoxia and critical pathways in the pathogenesis of cardiovascular disease in patients with OSA. This review will discuss the known mechanisms of vascular dysfunction in patients with OSA and their implications for cardiovascular disease.
UR - https://www.scopus.com/pages/publications/67649366023
UR - https://www.scopus.com/inward/citedby.url?scp=67649366023&partnerID=8YFLogxK
U2 - 10.1007/s10741-008-9112-z
DO - 10.1007/s10741-008-9112-z
M3 - Review article
C2 - 18807180
AN - SCOPUS:67649366023
SN - 1382-4147
VL - 14
SP - 143
EP - 153
JO - Heart Failure Reviews
JF - Heart Failure Reviews
IS - 3
ER -
