TY - JOUR
T1 - Occupationally Related Nickel Reactions
T2 - A Retrospective Analysis of the North American Contact Dermatitis Group Data 1998-2016
AU - Warshaw, Erin M.
AU - Schlarbaum, Jamie P.
AU - Dekoven, Joel G.
AU - Silverberg, Jonathan I.
AU - Zug, Kathryn A.
AU - Marks, James G.
AU - Belsito, Donald V.
AU - Mathias, Toby
AU - Reeder, Margo J.
AU - Atwater, Amber R.
AU - Maibach, Howard I.
AU - Sasseville, Denis
AU - Zirwas, Matthew J.
AU - Fransway, Anthony F.
AU - Pratt, Melanie D.
AU - Deleo, Vincent A.
AU - Fowler, Joseph F.
AU - Taylor, James S.
N1 - Funding Information:
†††Division of Dermatology, University of Ottawa, Ontario, Canada; ‡‡‡Department of Dermatology, Keck School of Medicine, Los Angeles, CA; §§§University of Louisville, KY; and ||||||Department of Dermatology, Cleveland Clinic, OH. Address reprint requests to Jamie P. Schlarbaum, BS, Dept 111K, 1 Veterans Dr, Minneapolis, MN 55417. E-mail: schla255@umn.edu. This study was supported in part by the Nickel Producers Environmental Research Association and in part with resources and the use of facilities at the Minneapolis Veterans Affairs Medical Center. The contents do not represent the views of the US Department of Veterans Affairs or the US Government. The authors have no conflicts of interest to declare.
Publisher Copyright:
© 2019 Lippincott Williams & Wilkins.
PY - 2019/9/1
Y1 - 2019/9/1
N2 - Background The epidemiology of nickel allergy in occupational settings is not well understood. Objective The aim of the study was to characterize occupationally related nickel allergy (ORNA). Methods This is a retrospective cross-sectional analysis of 44,378 patients patch tested by the North American Contact Dermatitis Group from 1998 to 2016. Characteristics of individuals with ORNA were compared with those with non-ORNA (NORNA). Results A total of 7928 (18.2%) individuals were positive to nickel sulfate 2.5%. Two hundred sixty-eight (3.4%) had ORNA. As compared with NORNA, ORNA was statistically associated with the male sex (41.0% vs 12.9%, P < 0.001), a diagnosis of irritant contact dermatitis (22.4% vs 12.0%, P < 0.001), and no history of eczema (81.7% vs 75.7%, P = 0.0217). The most common sites of ORNA dermatitis were hand (39.9%) and arm (18.1%), which were significantly more common than in NORNA (P < 0.0001). Sixteen industry categories and 22 occupation categories were identified for ORNA; the most common industries were durable goods manufacturing (24.6%) and personal services (15.7%), and the most frequent occupations were hairdressers/cosmetologists/barbers (14.3%), machine operators (9.3%), and health care workers (7.1%). Overall 30% of ORNA occupations were in metalworking. Of 215 ORNA sources identified, instruments/phones/other equipment (16.3%), vehicles/machinery (15.8%), and tools (15.3%) were the most common. Conclusions Occupational nickel allergy is distinct from nonoccupational nickel allergy.
AB - Background The epidemiology of nickel allergy in occupational settings is not well understood. Objective The aim of the study was to characterize occupationally related nickel allergy (ORNA). Methods This is a retrospective cross-sectional analysis of 44,378 patients patch tested by the North American Contact Dermatitis Group from 1998 to 2016. Characteristics of individuals with ORNA were compared with those with non-ORNA (NORNA). Results A total of 7928 (18.2%) individuals were positive to nickel sulfate 2.5%. Two hundred sixty-eight (3.4%) had ORNA. As compared with NORNA, ORNA was statistically associated with the male sex (41.0% vs 12.9%, P < 0.001), a diagnosis of irritant contact dermatitis (22.4% vs 12.0%, P < 0.001), and no history of eczema (81.7% vs 75.7%, P = 0.0217). The most common sites of ORNA dermatitis were hand (39.9%) and arm (18.1%), which were significantly more common than in NORNA (P < 0.0001). Sixteen industry categories and 22 occupation categories were identified for ORNA; the most common industries were durable goods manufacturing (24.6%) and personal services (15.7%), and the most frequent occupations were hairdressers/cosmetologists/barbers (14.3%), machine operators (9.3%), and health care workers (7.1%). Overall 30% of ORNA occupations were in metalworking. Of 215 ORNA sources identified, instruments/phones/other equipment (16.3%), vehicles/machinery (15.8%), and tools (15.3%) were the most common. Conclusions Occupational nickel allergy is distinct from nonoccupational nickel allergy.
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U2 - 10.1097/DER.0000000000000516
DO - 10.1097/DER.0000000000000516
M3 - Article
C2 - 31524759
AN - SCOPUS:85072190430
SN - 1710-3568
VL - 30
SP - 306
EP - 313
JO - Dermatitis
JF - Dermatitis
IS - 5
ER -