TY - JOUR
T1 - Occupations and the Risk of Head and Neck Cancer
T2 - A Pooled Analysis of the International Head and Neck Cancer Epidemiology (INHANCE) Consortium
AU - Khetan, Prerna
AU - Boffetta, Paolo
AU - Luce, Daniele
AU - Stucker, Isabelle
AU - Curado, Maria Paula
AU - Menezes, Ana
AU - Wunsch-Filho, Victor
AU - Ahrens, Wolfgang
AU - Lagiou, Pagona
AU - Serraino, Diego
AU - Richiardi, Lorenzo
AU - Kjaerheim, Kristina
AU - Conway, David
AU - Thomson, Peter
AU - Muscat, Joshua
AU - Mates, Dana
AU - Ramroth, Heribert
AU - Menvielle, Gwenn
AU - Vaughan, Thomas L.
AU - Brenner, Hermann
AU - Lee, Yuan Chin Amy
AU - La Vecchia, Carlo
AU - Hashibe, Mia
AU - Hashim, Dana
N1 - Publisher Copyright:
Copyright © 2019 American College of Occupational and Environmental Medicine.
PY - 2019/5/1
Y1 - 2019/5/1
N2 - Objective:To investigate the associations between head and neck cancer (HNC) risk and occupations.Methods:We harmonized data on occupations in a pooled analysis of 8839 HNC cases and 13,730 controls in International Head and Neck Cancer Epidemiology (INHANCE) consortium. Logistic regression was used to estimate odds ratios (ORs) for associations of occupations and HNC risk. Population attributable fraction (PAF) for occupations was calculated using the formula PEC×(OR-1)/OR.1Results:Trend of increasing HNC risk was found with increasing duration of employment for many occupations, including cooks (OR=1.36; 95% confidence interval [CI] 1.09 to 1.68), cleaners (OR=1.38; 95% CI 1.13 to 1.69), painters (OR=1.82; 95% CI 1.42 to 2.35). The PAF for a priori occupations was 14.5% (95% CI 7.1% to 21.9%) for HNC.Conclusions:We found associations between certain occupations and HNC risks, including for subsites, with a duration-response relationship.
AB - Objective:To investigate the associations between head and neck cancer (HNC) risk and occupations.Methods:We harmonized data on occupations in a pooled analysis of 8839 HNC cases and 13,730 controls in International Head and Neck Cancer Epidemiology (INHANCE) consortium. Logistic regression was used to estimate odds ratios (ORs) for associations of occupations and HNC risk. Population attributable fraction (PAF) for occupations was calculated using the formula PEC×(OR-1)/OR.1Results:Trend of increasing HNC risk was found with increasing duration of employment for many occupations, including cooks (OR=1.36; 95% confidence interval [CI] 1.09 to 1.68), cleaners (OR=1.38; 95% CI 1.13 to 1.69), painters (OR=1.82; 95% CI 1.42 to 2.35). The PAF for a priori occupations was 14.5% (95% CI 7.1% to 21.9%) for HNC.Conclusions:We found associations between certain occupations and HNC risks, including for subsites, with a duration-response relationship.
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U2 - 10.1097/JOM.0000000000001563
DO - 10.1097/JOM.0000000000001563
M3 - Article
C2 - 31268937
AN - SCOPUS:85069267777
SN - 1076-2752
VL - 61
SP - 397
EP - 404
JO - Journal of occupational and environmental medicine
JF - Journal of occupational and environmental medicine
IS - 5
ER -