Abstract
Results: OPP suppressed PaCa proliferation in a dosedependent manner. Its anti-invasive effects were validated by decreased expressions of MMP-9 and VEGF. Cell-cycle analysis demonstrated that cells were arrested in the S phase. OPP-induced apoptosis was associated with decrease in survivin and Bcl-XL expressions and increased expression of cleaved caspase-3, caspase-9 and PARP.
Background: Oil palm phenolics (OPP) or Palm Juice (PJ), a water soluble extract from the palm fruit (Elaies guineensis) has been documented to have anticarcinogenic activities in various cancer types.
Materials and Methods: To investigate OPP effects in pancreatic cancer (PaCa) cells, two PaCa cell lines (PANC-1 and BxPC-3) were treated with different OPP doses. The antiproliferative, apoptotic and anti-invasive properties of OPP were evaluated using MTS, cytoplasmic histone-DNA fragmentation and matrigel invasive assays, respectively.
Conclusion: Overall, our results demonstrate the anti-tumor effects of OPP on PaCa cells, providing initial evidence towards its potential therapeutic use.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 97-106 |
| Number of pages | 10 |
| Journal | Anticancer Research |
| Volume | 35 |
| Issue number | 1 |
| State | Published - Jan 1 2015 |
All Science Journal Classification (ASJC) codes
- Oncology
- Cancer Research
