On demand one-step generation of functional polymeric microparticles in droplet microfluidics

Xu Yu; Gong Cheng; Ming Da Zhou; Siyang Zheng

On demand one-step generation of functional polymeric microparticles in droplet microfluidics

Xu Yu, Gong Cheng, Ming Da Zhou, Siyang Zheng

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

This paper reports one-step synthesis of monodisperse functional poly(D, L-lactic-co-glycolic acid) (PLGA) microspheres by generation of reversed microemulsion droplets in aqueous phase inside microfluidic chips and controlled evaporation of the organic solvent. By controlling the flow rate of the microemulsion phase, functional PLGA polymeric microspheres with narrow size distribution and diameters in the range of ∼50-100 μm were obtained. As a demonstration of the versatility of the approach, fluorescent PLGA@QDs, magnetic PLGA@Fe₃O₄ and PLGA@CNTs polymeric microspheres were successfully generated by encapsulating the fluorescent CdTe: Zn²⁺ quantum dots (QDs), superparamagnetic Fe₃O₄ nanoparticles and water-soluble carbon nanotubes (CNTs), respectively.

Original language	English (US)
Title of host publication	18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014
Publisher	Chemical and Biological Microsystems Society
Pages	1235-1237
Number of pages	3
ISBN (Electronic)	9780979806476
State	Published - 2014
Event	18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014 - San Antonio, United States Duration: Oct 26 2014 → Oct 30 2014

Other

Other	18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014
Country/Territory	United States
City	San Antonio
Period	10/26/14 → 10/30/14

All Science Journal Classification (ASJC) codes

Control and Systems Engineering

Cite this

@inproceedings{54a3230dfdd84316b8268ec1bb0f5813,

title = "On demand one-step generation of functional polymeric microparticles in droplet microfluidics",

abstract = "This paper reports one-step synthesis of monodisperse functional poly(D, L-lactic-co-glycolic acid) (PLGA) microspheres by generation of reversed microemulsion droplets in aqueous phase inside microfluidic chips and controlled evaporation of the organic solvent. By controlling the flow rate of the microemulsion phase, functional PLGA polymeric microspheres with narrow size distribution and diameters in the range of ∼50-100 μm were obtained. As a demonstration of the versatility of the approach, fluorescent PLGA@QDs, magnetic PLGA@Fe3O4 and PLGA@CNTs polymeric microspheres were successfully generated by encapsulating the fluorescent CdTe: Zn2+ quantum dots (QDs), superparamagnetic Fe3O4 nanoparticles and water-soluble carbon nanotubes (CNTs), respectively.",

author = "Xu Yu and Gong Cheng and Zhou, {Ming Da} and Siyang Zheng",

year = "2014",

language = "English (US)",

pages = "1235--1237",

booktitle = "18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014",

publisher = "Chemical and Biological Microsystems Society",

note = "18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014 ; Conference date: 26-10-2014 Through 30-10-2014",

}

Yu, X, Cheng, G, Zhou, MD & Zheng, S 2014, On demand one-step generation of functional polymeric microparticles in droplet microfluidics. in 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014. Chemical and Biological Microsystems Society, pp. 1235-1237, 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014, San Antonio, United States, 10/26/14.

On demand one-step generation of functional polymeric microparticles in droplet microfluidics. / Yu, Xu; Cheng, Gong; Zhou, Ming Da et al.
18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014. Chemical and Biological Microsystems Society, 2014. p. 1235-1237.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

TY - GEN

T1 - On demand one-step generation of functional polymeric microparticles in droplet microfluidics

AU - Yu, Xu

AU - Cheng, Gong

AU - Zhou, Ming Da

AU - Zheng, Siyang

PY - 2014

Y1 - 2014

N2 - This paper reports one-step synthesis of monodisperse functional poly(D, L-lactic-co-glycolic acid) (PLGA) microspheres by generation of reversed microemulsion droplets in aqueous phase inside microfluidic chips and controlled evaporation of the organic solvent. By controlling the flow rate of the microemulsion phase, functional PLGA polymeric microspheres with narrow size distribution and diameters in the range of ∼50-100 μm were obtained. As a demonstration of the versatility of the approach, fluorescent PLGA@QDs, magnetic PLGA@Fe3O4 and PLGA@CNTs polymeric microspheres were successfully generated by encapsulating the fluorescent CdTe: Zn2+ quantum dots (QDs), superparamagnetic Fe3O4 nanoparticles and water-soluble carbon nanotubes (CNTs), respectively.

AB - This paper reports one-step synthesis of monodisperse functional poly(D, L-lactic-co-glycolic acid) (PLGA) microspheres by generation of reversed microemulsion droplets in aqueous phase inside microfluidic chips and controlled evaporation of the organic solvent. By controlling the flow rate of the microemulsion phase, functional PLGA polymeric microspheres with narrow size distribution and diameters in the range of ∼50-100 μm were obtained. As a demonstration of the versatility of the approach, fluorescent PLGA@QDs, magnetic PLGA@Fe3O4 and PLGA@CNTs polymeric microspheres were successfully generated by encapsulating the fluorescent CdTe: Zn2+ quantum dots (QDs), superparamagnetic Fe3O4 nanoparticles and water-soluble carbon nanotubes (CNTs), respectively.

UR - http://www.scopus.com/inward/record.url?scp=84941650131&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84941650131&partnerID=8YFLogxK

M3 - Conference contribution

AN - SCOPUS:84941650131

SP - 1235

EP - 1237

BT - 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014

PB - Chemical and Biological Microsystems Society

T2 - 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014

Y2 - 26 October 2014 through 30 October 2014

ER -

On demand one-step generation of functional polymeric microparticles in droplet microfluidics

Abstract

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All Science Journal Classification (ASJC) codes

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