TY - JOUR
T1 - On the mechanism of fructose 1,6-diphosphatase
T2 - Inhibition by methyl d-fructoside 1,6-diphosphate
AU - Benkovic, S. J.
AU - de Maine, M. M.
AU - Kleinschuster, J. J.
N1 - Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 1970/7
Y1 - 1970/7
N2 - From a comparison of the effects of potential inhibitors it is concluded that the furanose configuration of fructose 1,6-diphosphate is utilized by FDPase. The partial competitive inhibitor methyl d-fructoside 1,6-diphosphate, apparently induces a conformational change that permits acetylation of the active site. The probable importance of the C-2 hydroxyl of the sugar phosphate in the mechanism of FDPase is discussed.
AB - From a comparison of the effects of potential inhibitors it is concluded that the furanose configuration of fructose 1,6-diphosphate is utilized by FDPase. The partial competitive inhibitor methyl d-fructoside 1,6-diphosphate, apparently induces a conformational change that permits acetylation of the active site. The probable importance of the C-2 hydroxyl of the sugar phosphate in the mechanism of FDPase is discussed.
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U2 - 10.1016/0003-9861(70)90068-8
DO - 10.1016/0003-9861(70)90068-8
M3 - Article
C2 - 4320534
AN - SCOPUS:0014813847
SN - 0003-9861
VL - 139
SP - 248
EP - 251
JO - Archives of Biochemistry and Biophysics
JF - Archives of Biochemistry and Biophysics
IS - 1
ER -