On the squid axon membrane's response to sequential voltage and current clamps

J. W. Moore; N. Stockbridge; S. J. Schiff

doi:10.1016/S0006-3495(82)84482-2

On the squid axon membrane's response to sequential voltage and current clamps

J. W. Moore, N. Stockbridge, S. J. Schiff

Research output: Contribution to journal › Article › peer-review

Abstract

Starzak and Starzak (1978. IEEE Trans. Biomed. Eng. 25:201–204.) proposed that, in cyclic application of current and voltage-clamps, the fidelity of the match of the output current with the original stimulus could be used to measure the spatial uniformity of voltage in a membrane. However, they failed to find such a match in experiments on either squid axons or an electronic model of a membrane patch. Computer simulations of such experiments show that the failure to return the initial pattern may arise from shortcomings of the instruments or instability of membrane characteristics. Logical arguments show that such cyclic experiments are not able to provide information about spatial gradients of membrane voltage.

Original language	English (US)
Pages (from-to)	259-262
Number of pages	4
Journal	Biophysical journal
Volume	40
Issue number	3
DOIs	https://doi.org/10.1016/S0006-3495(82)84482-2
State	Published - 1982

All Science Journal Classification (ASJC) codes

Biophysics

Access to Document

10.1016/S0006-3495(82)84482-2

Cite this

@article{bdf8c81e234442e2a8b4602aa8ba3ed1,

title = "On the squid axon membrane's response to sequential voltage and current clamps",

abstract = "Starzak and Starzak (1978. IEEE Trans. Biomed. Eng. 25:201–204.) proposed that, in cyclic application of current and voltage-clamps, the fidelity of the match of the output current with the original stimulus could be used to measure the spatial uniformity of voltage in a membrane. However, they failed to find such a match in experiments on either squid axons or an electronic model of a membrane patch. Computer simulations of such experiments show that the failure to return the initial pattern may arise from shortcomings of the instruments or instability of membrane characteristics. Logical arguments show that such cyclic experiments are not able to provide information about spatial gradients of membrane voltage.",

author = "Moore, {J. W.} and N. Stockbridge and Schiff, {S. J.}",

year = "1982",

doi = "10.1016/S0006-3495(82)84482-2",

language = "English (US)",

volume = "40",

pages = "259--262",

journal = "Biophysical journal",

issn = "0006-3495",

publisher = "Elsevier B.V.",

number = "3",

}

TY - JOUR

T1 - On the squid axon membrane's response to sequential voltage and current clamps

AU - Moore, J. W.

AU - Stockbridge, N.

AU - Schiff, S. J.

PY - 1982

Y1 - 1982

N2 - Starzak and Starzak (1978. IEEE Trans. Biomed. Eng. 25:201–204.) proposed that, in cyclic application of current and voltage-clamps, the fidelity of the match of the output current with the original stimulus could be used to measure the spatial uniformity of voltage in a membrane. However, they failed to find such a match in experiments on either squid axons or an electronic model of a membrane patch. Computer simulations of such experiments show that the failure to return the initial pattern may arise from shortcomings of the instruments or instability of membrane characteristics. Logical arguments show that such cyclic experiments are not able to provide information about spatial gradients of membrane voltage.

AB - Starzak and Starzak (1978. IEEE Trans. Biomed. Eng. 25:201–204.) proposed that, in cyclic application of current and voltage-clamps, the fidelity of the match of the output current with the original stimulus could be used to measure the spatial uniformity of voltage in a membrane. However, they failed to find such a match in experiments on either squid axons or an electronic model of a membrane patch. Computer simulations of such experiments show that the failure to return the initial pattern may arise from shortcomings of the instruments or instability of membrane characteristics. Logical arguments show that such cyclic experiments are not able to provide information about spatial gradients of membrane voltage.

UR - http://www.scopus.com/inward/record.url?scp=0020455294&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020455294&partnerID=8YFLogxK

U2 - 10.1016/S0006-3495(82)84482-2

DO - 10.1016/S0006-3495(82)84482-2

M3 - Article

C2 - 7183340

AN - SCOPUS:0020455294

SN - 0006-3495

VL - 40

SP - 259

EP - 262

JO - Biophysical journal

JF - Biophysical journal

IS - 3

ER -

On the squid axon membrane's response to sequential voltage and current clamps

Abstract

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this