One-carbon metabolism and schizophrenia: current challenges and future directions

M. O. Krebs, Alfredo Bellon, Gaell Mainguy, T. M. Jay, Helge Frieling

Research output: Contribution to journalArticlepeer-review

72 Scopus citations


Schizophrenia is a heterogeneous disease generally considered to result from a combination of heritable and environmental factors. Although its pathophysiology has not been fully determined, biological studies support the involvement of several possible components including altered DNA methylation, abnormal glutamatergic transmission, altered mitochondrial function, folate deficiency and high maternal homocysteine levels. Although these factors have been explored separately, they all involve one-carbon (C1) metabolism. Furthermore, C1 metabolism is well positioned to integrate gene-environment interactions by influencing epigenetic regulation. Here, we discuss the potential roles of C1 metabolism in the pathophysiology of schizophrenia. Understanding the contribution of these mechanisms could yield new therapeutic approaches aiming to counteract disease onset or progression.

Original languageEnglish (US)
Pages (from-to)562-570
Number of pages9
JournalTrends in Molecular Medicine
Issue number12
StatePublished - Dec 2009

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Molecular Biology


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