Opiate antagonists and the modification of heroin self administration behavior in man: an experimental study

J. L. Altman; R. E. Meyer; S. M. Mirin; H. B. McNamee

doi:10.3109/10826087609056165

Opiate antagonists and the modification of heroin self administration behavior in man: an experimental study

J. L. Altman, R. E. Meyer, S. M. Mirin, H. B. McNamee

Department of Psychiatry and Behavioral Health

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

The heroin self administration behavior of 8 inpatient heroin addicts was examined for 10 days under blocked (i.e., following ingestion of narcotic antagonists naloxone or naltrexone) and unblocked (no antagonist) conditions. In the unblocked state, subjects injected all the available heroin, but they ceased heroin use almost completely following antagonist administration. Possible explanations for these results are discussed along with their implications for treatment.

Original language	English (US)
Pages (from-to)	485-499
Number of pages	15
Journal	Unknown Journal
Volume	11
Issue number	3
DOIs	https://doi.org/10.3109/10826087609056165
State	Published - Jan 1 1976

All Science Journal Classification (ASJC) codes

Medicine (miscellaneous)

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10.3109/10826087609056165

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AB - The heroin self administration behavior of 8 inpatient heroin addicts was examined for 10 days under blocked (i.e., following ingestion of narcotic antagonists naloxone or naltrexone) and unblocked (no antagonist) conditions. In the unblocked state, subjects injected all the available heroin, but they ceased heroin use almost completely following antagonist administration. Possible explanations for these results are discussed along with their implications for treatment.

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Opiate antagonists and the modification of heroin self administration behavior in man: an experimental study

Abstract

All Science Journal Classification (ASJC) codes

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