Abstract
Naltrexone (NTX), an opiate antagonist, had an inhibitory effect on the growth of S20Y neuroblastoma (NB) in A Jax mice. Daily injections of 0.1 mg/kg NTX resulted in a 69% tumor take, 70% delay in time prior to tumor appearance, and a 60% increase in median survival time. Inoculation of NB in control mice resulted in 100% tumor take within 15 days. The pattern and incidence of metastases of NTX and control mice were similar. These results show that NTX has antineoplastic activity, and suggests a role for the endogenous opioid system in neuro-oncogenic events.
Original language | English (US) |
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Pages (from-to) | 89-94 |
Number of pages | 6 |
Journal | Cancer Letters |
Volume | 21 |
Issue number | 1 |
DOIs | |
State | Published - Nov 1983 |
All Science Journal Classification (ASJC) codes
- Oncology
- Cancer Research