Opioid antagonists inhibit the growth of metastatic murine neuroblastoma

Ian S. Zagon; Patricia J. McLaughlin

doi:10.1016/0304-3835(83)90087-3

Opioid antagonists inhibit the growth of metastatic murine neuroblastoma

Ian S. Zagon, Patricia J. McLaughlin

Research output: Contribution to journal › Article › peer-review

42 Scopus citations

Abstract

Naltrexone (NTX), an opiate antagonist, had an inhibitory effect on the growth of S20Y neuroblastoma (NB) in A Jax mice. Daily injections of 0.1 mg/kg NTX resulted in a 69% tumor take, 70% delay in time prior to tumor appearance, and a 60% increase in median survival time. Inoculation of NB in control mice resulted in 100% tumor take within 15 days. The pattern and incidence of metastases of NTX and control mice were similar. These results show that NTX has antineoplastic activity, and suggests a role for the endogenous opioid system in neuro-oncogenic events.

Original language	English (US)
Pages (from-to)	89-94
Number of pages	6
Journal	Cancer Letters
Volume	21
Issue number	1
DOIs	https://doi.org/10.1016/0304-3835(83)90087-3
State	Published - Nov 1983

All Science Journal Classification (ASJC) codes

Oncology
Cancer Research

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10.1016/0304-3835(83)90087-3

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title = "Opioid antagonists inhibit the growth of metastatic murine neuroblastoma",

abstract = "Naltrexone (NTX), an opiate antagonist, had an inhibitory effect on the growth of S20Y neuroblastoma (NB) in A Jax mice. Daily injections of 0.1 mg/kg NTX resulted in a 69% tumor take, 70% delay in time prior to tumor appearance, and a 60% increase in median survival time. Inoculation of NB in control mice resulted in 100% tumor take within 15 days. The pattern and incidence of metastases of NTX and control mice were similar. These results show that NTX has antineoplastic activity, and suggests a role for the endogenous opioid system in neuro-oncogenic events.",

author = "Zagon, {Ian S.} and McLaughlin, {Patricia J.}",

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AU - Zagon, Ian S.

AU - McLaughlin, Patricia J.

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AB - Naltrexone (NTX), an opiate antagonist, had an inhibitory effect on the growth of S20Y neuroblastoma (NB) in A Jax mice. Daily injections of 0.1 mg/kg NTX resulted in a 69% tumor take, 70% delay in time prior to tumor appearance, and a 60% increase in median survival time. Inoculation of NB in control mice resulted in 100% tumor take within 15 days. The pattern and incidence of metastases of NTX and control mice were similar. These results show that NTX has antineoplastic activity, and suggests a role for the endogenous opioid system in neuro-oncogenic events.

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JF - Cancer Letters

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Opioid antagonists inhibit the growth of metastatic murine neuroblastoma

Abstract

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