Abstract
Naltrexone (NTX), an opiate antagonist, had an inhibitory effect on the growth of S20Y neuroblastoma (NB) in A Jax mice. Daily injections of 0.1 mg/kg NTX resulted in a 69% tumor take, 70% delay in time prior to tumor appearance, and a 60% increase in median survival time. Inoculation of NB in control mice resulted in 100% tumor take within 15 days. The pattern and incidence of metastases of NTX and control mice were similar. These results show that NTX has antineoplastic activity, and suggests a role for the endogenous opioid system in neuro-oncogenic events.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 89-94 |
| Number of pages | 6 |
| Journal | Cancer Letters |
| Volume | 21 |
| Issue number | 1 |
| DOIs | |
| State | Published - Nov 1983 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
All Science Journal Classification (ASJC) codes
- Oncology
- Cancer Research
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