Opioid growth factor (OGF) inhibits the progression of human squamous cell carcinoma of the head and neck transplanted into nude mice

Patricia J. McLaughlin; Roger J. Levin; Ian S. Zagon

doi:10.1016/S0304-3835(03)00341-0

Opioid growth factor (OGF) inhibits the progression of human squamous cell carcinoma of the head and neck transplanted into nude mice

Patricia J. McLaughlin, Roger J. Levin, Ian S. Zagon

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

Opioid growth factor (OGF) interacts with the OGF receptor (OGFr) and serves as a native inhibitory growth factor. OGF and OGFr are present in squamous cell carcinoma of the head and neck (SCCHN), and OGF represses the replication of SCCHN in tissue culture. In this study, OGF-treated nude mice with xenografts of SCCHN displayed delays in tumor appearance and had reduced tumor size compared to controls. OGF activity was receptor-mediated. Opioid-receptor blockade by the potent opioid antagonist, naltrexone, stimulated tumorigenic processes. Both OGF and OGFr were detected in the tumors by immunohistochemistry, and OGFr was characterized by receptor binding analysis. These results indicate that the OGF-OGFr axis functions in vivo, OGF is a constitutively active molecule, and OGF modulation of SCCHN may have clinical application.

Original language	English (US)
Pages (from-to)	209-217
Number of pages	9
Journal	Cancer Letters
Volume	199
Issue number	2
DOIs	https://doi.org/10.1016/S0304-3835(03)00341-0
State	Published - Sep 25 2003

All Science Journal Classification (ASJC) codes

Oncology
Cancer Research

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10.1016/S0304-3835(03)00341-0

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title = "Opioid growth factor (OGF) inhibits the progression of human squamous cell carcinoma of the head and neck transplanted into nude mice",

abstract = "Opioid growth factor (OGF) interacts with the OGF receptor (OGFr) and serves as a native inhibitory growth factor. OGF and OGFr are present in squamous cell carcinoma of the head and neck (SCCHN), and OGF represses the replication of SCCHN in tissue culture. In this study, OGF-treated nude mice with xenografts of SCCHN displayed delays in tumor appearance and had reduced tumor size compared to controls. OGF activity was receptor-mediated. Opioid-receptor blockade by the potent opioid antagonist, naltrexone, stimulated tumorigenic processes. Both OGF and OGFr were detected in the tumors by immunohistochemistry, and OGFr was characterized by receptor binding analysis. These results indicate that the OGF-OGFr axis functions in vivo, OGF is a constitutively active molecule, and OGF modulation of SCCHN may have clinical application.",

author = "McLaughlin, {Patricia J.} and Levin, {Roger J.} and Zagon, {Ian S.}",

note = "Funding Information: The authors would like to thank Dr Farhan Taghizadeh and Colleen Roesener for technical assistance with the nude mouse studies, and Jamie Fry and Amanda Dunkle for immunohistochemistry and preparation of the figures. We are grateful to Dr James W. Griffith of the Department of Comparative Medicine for assistance in assessing pathology. This study was supported in part by grants from the External Research Division of Philip Morris, and the Pennsylvania Department of Health. The Department specifically disclaims responsibility for any analyses, interpretations or conclusions.",

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doi = "10.1016/S0304-3835(03)00341-0",

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T1 - Opioid growth factor (OGF) inhibits the progression of human squamous cell carcinoma of the head and neck transplanted into nude mice

AU - McLaughlin, Patricia J.

AU - Levin, Roger J.

AU - Zagon, Ian S.

N1 - Funding Information: The authors would like to thank Dr Farhan Taghizadeh and Colleen Roesener for technical assistance with the nude mouse studies, and Jamie Fry and Amanda Dunkle for immunohistochemistry and preparation of the figures. We are grateful to Dr James W. Griffith of the Department of Comparative Medicine for assistance in assessing pathology. This study was supported in part by grants from the External Research Division of Philip Morris, and the Pennsylvania Department of Health. The Department specifically disclaims responsibility for any analyses, interpretations or conclusions.

PY - 2003/9/25

Y1 - 2003/9/25

N2 - Opioid growth factor (OGF) interacts with the OGF receptor (OGFr) and serves as a native inhibitory growth factor. OGF and OGFr are present in squamous cell carcinoma of the head and neck (SCCHN), and OGF represses the replication of SCCHN in tissue culture. In this study, OGF-treated nude mice with xenografts of SCCHN displayed delays in tumor appearance and had reduced tumor size compared to controls. OGF activity was receptor-mediated. Opioid-receptor blockade by the potent opioid antagonist, naltrexone, stimulated tumorigenic processes. Both OGF and OGFr were detected in the tumors by immunohistochemistry, and OGFr was characterized by receptor binding analysis. These results indicate that the OGF-OGFr axis functions in vivo, OGF is a constitutively active molecule, and OGF modulation of SCCHN may have clinical application.

AB - Opioid growth factor (OGF) interacts with the OGF receptor (OGFr) and serves as a native inhibitory growth factor. OGF and OGFr are present in squamous cell carcinoma of the head and neck (SCCHN), and OGF represses the replication of SCCHN in tissue culture. In this study, OGF-treated nude mice with xenografts of SCCHN displayed delays in tumor appearance and had reduced tumor size compared to controls. OGF activity was receptor-mediated. Opioid-receptor blockade by the potent opioid antagonist, naltrexone, stimulated tumorigenic processes. Both OGF and OGFr were detected in the tumors by immunohistochemistry, and OGFr was characterized by receptor binding analysis. These results indicate that the OGF-OGFr axis functions in vivo, OGF is a constitutively active molecule, and OGF modulation of SCCHN may have clinical application.

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JO - Cancer Letters

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Opioid growth factor (OGF) inhibits the progression of human squamous cell carcinoma of the head and neck transplanted into nude mice

Abstract

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