Optimal design of combined ultrasound and multispectral photoacoustic deep tissue imaging devices using hybrid simulation platform

Sumit Agrawal, Ajay Dangi, Neilesh Frings, Hussain Albahrani, Salim Bin Ghouth, Sri Rajasekhar Kothapalli

Research output: Chapter in Book/Report/Conference proceedingConference contribution

11 Scopus citations


In recent years, conventional ultrasound (US) imaging devices have been adapted with the photoacoustic (PA) imaging capabilities to simultaneously provide both anatomical and molecular optical contrasts of soft biological tissues. To help optimize the design parameters of such dual modality imaging devices, we present a numerical simulation approach for Bmode beamformed US and multispectral PA imaging using a linear ultrasound transducer array surrounded by a light source. We combined the finite element based simulation platforms for ultrasound and light propagation, K-wave and NIRFast respectively, to model the ultrasound and photoacoustic effects in deep tissue, and created an effective hybrid platform for simulating US and multispectral PA imaging of different configurations. We also developed and applied a spectral unmixing algorithm on multispectral photoacoustic images, obtained from multiple optical wavelengths, to map different molecules (e.g., Indocyanogreen (ICG), Deoxyhemoglobin (Hb), and Oxyhemoglobin (HbO2)) present inside the tissue background. The multi-spectral plots and unmixed spectral images clearly delineated the molecular contrast arising from different regions inside the tissue. The presented simulation platform allows for optimization of key design parameters of both US and PA imaging devices, such as the size of ultrasonic transducer array, and size and the distribution of light sources. Our results demonstrate that the ability to mimic the imaging performance of such dual modality deep tissue-imaging device will help to achieve high molecular sensitivity for the targeted clinical application, thus functioning as a powerful tool for medical device design.

Original languageEnglish (US)
Title of host publicationPhotons Plus Ultrasound
Subtitle of host publicationImaging and Sensing 2019
EditorsLihong V. Wang, Alexander A. Oraevsky
ISBN (Electronic)9781510623989
StatePublished - 2019
EventPhotons Plus Ultrasound: Imaging and Sensing 2019 - San Francisco, United States
Duration: Feb 3 2019Feb 6 2019

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
ISSN (Print)1605-7422


ConferencePhotons Plus Ultrasound: Imaging and Sensing 2019
Country/TerritoryUnited States
CitySan Francisco

All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Biomaterials
  • Radiology Nuclear Medicine and imaging


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