ORAI channels in cellular remodeling of cardiorespiratory disease

Martin Johnson; Mohamed Trebak

doi:10.1016/j.ceca.2019.01.005

ORAI channels in cellular remodeling of cardiorespiratory disease

Martin Johnson
, Mohamed Trebak

Research output: Contribution to journal › Review article › peer-review

34 Scopus citations

Abstract

Cardiorespiratory disease, which includes systemic arterial hypertension, restenosis, atherosclerosis, pulmonary arterial hypertension, asthma, and chronic obstructive pulmonary disease (COPD) are highly prevalent and devastating diseases with limited therapeutic modalities. A common pathophysiological theme to these diseases is cellular remodeling, which is contributed by changes in expression and activation of ion channels critical for either excitability or growth. Calcium (Ca ²⁺ ) signaling and specifically ORAI Ca ²⁺ channels have emerged as significant regulators of smooth muscle, endothelial, epithelial, platelet, and immune cell remodeling. This review details the dysregulation of ORAI in cardiorespiratory diseases, and how this dysregulation of ORAI contributes to cellular remodeling.

Original language	English (US)
Pages (from-to)	1-10
Number of pages	10
Journal	Cell Calcium
Volume	79
DOIs	https://doi.org/10.1016/j.ceca.2019.01.005
State	Published - May 2019

All Science Journal Classification (ASJC) codes

Physiology
Molecular Biology
Cell Biology

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10.1016/j.ceca.2019.01.005

Cite this

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title = "ORAI channels in cellular remodeling of cardiorespiratory disease",

abstract = " Cardiorespiratory disease, which includes systemic arterial hypertension, restenosis, atherosclerosis, pulmonary arterial hypertension, asthma, and chronic obstructive pulmonary disease (COPD) are highly prevalent and devastating diseases with limited therapeutic modalities. A common pathophysiological theme to these diseases is cellular remodeling, which is contributed by changes in expression and activation of ion channels critical for either excitability or growth. Calcium (Ca 2+ ) signaling and specifically ORAI Ca 2+ channels have emerged as significant regulators of smooth muscle, endothelial, epithelial, platelet, and immune cell remodeling. This review details the dysregulation of ORAI in cardiorespiratory diseases, and how this dysregulation of ORAI contributes to cellular remodeling.",

author = "Martin Johnson and Mohamed Trebak",

note = "Funding Information: Research in the authors{\textquoteright} laboratories is supported by grants R01HL123364 , R01HL097111 and R21AG050072 from the National Institutes of Health and by grant NPRP8-110-3-021 from the Qatar National Research Fund (QNRF) to M.T. and by a training grant TL1TR002016 from the National Center for Advancing Translational Sciences of the National Institute of Health to M.J. Publisher Copyright: {\textcopyright} 2019",

year = "2019",

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doi = "10.1016/j.ceca.2019.01.005",

language = "English (US)",

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AU - Johnson, Martin

AU - Trebak, Mohamed

N1 - Funding Information: Research in the authors’ laboratories is supported by grants R01HL123364 , R01HL097111 and R21AG050072 from the National Institutes of Health and by grant NPRP8-110-3-021 from the Qatar National Research Fund (QNRF) to M.T. and by a training grant TL1TR002016 from the National Center for Advancing Translational Sciences of the National Institute of Health to M.J. Publisher Copyright: © 2019

PY - 2019/5

Y1 - 2019/5

N2 - Cardiorespiratory disease, which includes systemic arterial hypertension, restenosis, atherosclerosis, pulmonary arterial hypertension, asthma, and chronic obstructive pulmonary disease (COPD) are highly prevalent and devastating diseases with limited therapeutic modalities. A common pathophysiological theme to these diseases is cellular remodeling, which is contributed by changes in expression and activation of ion channels critical for either excitability or growth. Calcium (Ca 2+ ) signaling and specifically ORAI Ca 2+ channels have emerged as significant regulators of smooth muscle, endothelial, epithelial, platelet, and immune cell remodeling. This review details the dysregulation of ORAI in cardiorespiratory diseases, and how this dysregulation of ORAI contributes to cellular remodeling.

AB - Cardiorespiratory disease, which includes systemic arterial hypertension, restenosis, atherosclerosis, pulmonary arterial hypertension, asthma, and chronic obstructive pulmonary disease (COPD) are highly prevalent and devastating diseases with limited therapeutic modalities. A common pathophysiological theme to these diseases is cellular remodeling, which is contributed by changes in expression and activation of ion channels critical for either excitability or growth. Calcium (Ca 2+ ) signaling and specifically ORAI Ca 2+ channels have emerged as significant regulators of smooth muscle, endothelial, epithelial, platelet, and immune cell remodeling. This review details the dysregulation of ORAI in cardiorespiratory diseases, and how this dysregulation of ORAI contributes to cellular remodeling.

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U2 - 10.1016/j.ceca.2019.01.005

DO - 10.1016/j.ceca.2019.01.005

M3 - Review article

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VL - 79

SP - 1

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JO - Cell Calcium

JF - Cell Calcium

ER -

ORAI channels in cellular remodeling of cardiorespiratory disease

Abstract

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