TY - JOUR
T1 - Osteoblasts and osteoclasts express PEDF, VEGF-A isoforms, and VEGF receptors
T2 - Possible mediators of angiogenesis and matrix remodeling in the bone
AU - Tombran-Tink, J.
AU - Barnstable, C. J.
N1 - Funding Information:
We thank Dr. Mark Horowtiz of the Yale Core Center for Musculoskeletal Disorders (supported by NIH Grant AR46032) for osteoblast and osteoclast cultures, Steve Viviano and Adrienne LaRue (YALE), and Nuria Lara and Sam Apricio (UMKC) for excellent technical assistance. This work was supported by grants from the NIH and the David Woods Kemper Memorial Foundation.
PY - 2004/4/2
Y1 - 2004/4/2
N2 - Pigment epithelial derived factor (PEDF) is one of the most effective inhibitors of angiogenesis described so far, especially in controlling the growth of blood vessels in the eye. We now describe the localization of PEDF in regions of active bone formation in the mid-gestation mouse embryo and its specific and high levels of secretion by osteoblasts. PEDF is detected to a lesser extent in osteoclasts as well. The proangiogenic factors, VEGF and its receptors VEGF-R1 and VEGF-R2, are also expressed by both osteoblasts and osteoclasts. These findings suggest that bone angiogenesis and matrix remodeling may be mediated both by PEDF and by VEGF.
AB - Pigment epithelial derived factor (PEDF) is one of the most effective inhibitors of angiogenesis described so far, especially in controlling the growth of blood vessels in the eye. We now describe the localization of PEDF in regions of active bone formation in the mid-gestation mouse embryo and its specific and high levels of secretion by osteoblasts. PEDF is detected to a lesser extent in osteoclasts as well. The proangiogenic factors, VEGF and its receptors VEGF-R1 and VEGF-R2, are also expressed by both osteoblasts and osteoclasts. These findings suggest that bone angiogenesis and matrix remodeling may be mediated both by PEDF and by VEGF.
UR - http://www.scopus.com/inward/record.url?scp=1542616911&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=1542616911&partnerID=8YFLogxK
U2 - 10.1016/j.bbrc.2004.02.076
DO - 10.1016/j.bbrc.2004.02.076
M3 - Article
C2 - 15020256
AN - SCOPUS:1542616911
SN - 0006-291X
VL - 316
SP - 573
EP - 579
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
IS - 2
ER -