Osteopontin identified as colon cancer tumor progression marker

Deepak Agrawal, Tingan Chen, Rosalyn Irby, John Quackenbush, Ann F. Chambers, Marianna Szabo, Alan Cantor, Domenico Coppola, Timothy J. Yeatman

Research output: Contribution to journalArticlepeer-review

49 Scopus citations


Identifying molecular markers for colon cancer is a top priority. Using a pooled sample approach with Affymetrix GeneChip technology, we assayed colon cancers derived from a series of clinical stages to identify molecular markers of potential prognostic value. Of 12 000 genes assessed, osteopontin emerged as the leading candidate tumor progression marker. Osteopontin is a secreted glycoprotein known to bind integrins and CD44. Its actual molecular function remains elusive but its increased expression correlates strongly with tumor progression.

Original languageEnglish (US)
Pages (from-to)1041-1043
Number of pages3
JournalComptes Rendus - Biologies
Issue number10-11
StatePublished - 2003

All Science Journal Classification (ASJC) codes

  • General Biochemistry, Genetics and Molecular Biology
  • General Immunology and Microbiology
  • General Agricultural and Biological Sciences


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