Osteopontin identified as colon cancer tumor progression marker

Deepak Agrawal; Tingan Chen; Rosalyn Irby; John Quackenbush; Ann F. Chambers; Marianna Szabo; Alan Cantor; Domenico Coppola; Timothy J. Yeatman

doi:10.1016/j.crvi.2003.09.007

Osteopontin identified as colon cancer tumor progression marker

Deepak Agrawal, Tingan Chen, Rosalyn Irby, John Quackenbush, Ann F. Chambers, Marianna Szabo, Alan Cantor, Domenico Coppola, Timothy J. Yeatman

Research output: Contribution to journal › Article › peer-review

50 Scopus citations

Abstract

Identifying molecular markers for colon cancer is a top priority. Using a pooled sample approach with Affymetrix GeneChip technology, we assayed colon cancers derived from a series of clinical stages to identify molecular markers of potential prognostic value. Of 12 000 genes assessed, osteopontin emerged as the leading candidate tumor progression marker. Osteopontin is a secreted glycoprotein known to bind integrins and CD44. Its actual molecular function remains elusive but its increased expression correlates strongly with tumor progression.

Original language	English (US)
Pages (from-to)	1041-1043
Number of pages	3
Journal	Comptes Rendus - Biologies
Volume	326
Issue number	10-11
DOIs	https://doi.org/10.1016/j.crvi.2003.09.007
State	Published - 2003

All Science Journal Classification (ASJC) codes

General Biochemistry, Genetics and Molecular Biology
General Immunology and Microbiology
General Agricultural and Biological Sciences

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10.1016/j.crvi.2003.09.007

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abstract = "Identifying molecular markers for colon cancer is a top priority. Using a pooled sample approach with Affymetrix GeneChip technology, we assayed colon cancers derived from a series of clinical stages to identify molecular markers of potential prognostic value. Of 12 000 genes assessed, osteopontin emerged as the leading candidate tumor progression marker. Osteopontin is a secreted glycoprotein known to bind integrins and CD44. Its actual molecular function remains elusive but its increased expression correlates strongly with tumor progression.",

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doi = "10.1016/j.crvi.2003.09.007",

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AU - Agrawal, Deepak

AU - Chen, Tingan

AU - Irby, Rosalyn

AU - Quackenbush, John

AU - Chambers, Ann F.

AU - Szabo, Marianna

AU - Cantor, Alan

AU - Coppola, Domenico

AU - Yeatman, Timothy J.

PY - 2003

Y1 - 2003

N2 - Identifying molecular markers for colon cancer is a top priority. Using a pooled sample approach with Affymetrix GeneChip technology, we assayed colon cancers derived from a series of clinical stages to identify molecular markers of potential prognostic value. Of 12 000 genes assessed, osteopontin emerged as the leading candidate tumor progression marker. Osteopontin is a secreted glycoprotein known to bind integrins and CD44. Its actual molecular function remains elusive but its increased expression correlates strongly with tumor progression.

AB - Identifying molecular markers for colon cancer is a top priority. Using a pooled sample approach with Affymetrix GeneChip technology, we assayed colon cancers derived from a series of clinical stages to identify molecular markers of potential prognostic value. Of 12 000 genes assessed, osteopontin emerged as the leading candidate tumor progression marker. Osteopontin is a secreted glycoprotein known to bind integrins and CD44. Its actual molecular function remains elusive but its increased expression correlates strongly with tumor progression.

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EP - 1043

JO - Comptes Rendus - Biologies

JF - Comptes Rendus - Biologies

IS - 10-11

ER -

Osteopontin identified as colon cancer tumor progression marker

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

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