O⁶-pyridyloxobutylguanine adducts contribute to the mutagenic properties of pyridyloxobutylating agents

Keyphrases

• 2-Butanone 33%
• 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone 33%
• Adverse Effects 33%
• Alkylating Agents 66%
• Butyl 33%
• Carcinogen 33%
• Carcinogenic Effects 100%
• DNA Adducts 33%
• Guanine 33%
• Human Carcinogen 33%
• Miscoding 33%
• Mutagenic Effects 33%
• Mutagenicity 66%
• N'-nitrosonornicotine 100%
• N-nitrosamines 33%
• O6-methylguanine 33%
• O6-methylguanine-DNA Methyltransferase 33%
• Pyridyl 66%
• Repair Proteins 33%
• Salmonella Enterica Serovar Typhimurium (S. Typhimurium) 33%

Pharmacology, Toxicology and Pharmaceutical Science

• 2 Butanone 33%
• 4 (Methylnitrosamino) 1 (3 Pyridyl) 1 Butanone 33%
• 6 O Alkylguanine DNA Alkyltransferase 33%
• Alkylating Agent 66%
• Carcinogen 66%
• Guanine 33%
• Mutagenicity 66%
• N-Nitrosonornicotine 100%
• Nicotine-Derived Nitrosamine Ketone 100%
• Salmonella Enterica Serovar Typhimurium 33%
• Tobacco-Specific Nitrosamines 33%