Outcomes and toxicities in patients treated with definitive focal therapy for primary prostate cancer: Systematic review

Atallah Baydoun; Bryan Traughber; Nathan Morris; Michella Abi Zeid Daou; Michael McGraw; Tarun K. Podder; Raymond F. Muzic; Simon S. Lo; Lee E. Ponsky; Mitchell MacHtay; Rodney Ellis

doi:10.2217/fon-2016-0354

Outcomes and toxicities in patients treated with definitive focal therapy for primary prostate cancer: Systematic review

Atallah Baydoun, Bryan Traughber, Nathan Morris, Michella Abi Zeid Daou, Michael McGraw, Tarun K. Podder, Raymond F. Muzic, Simon S. Lo, Lee E. Ponsky, Mitchell MacHtay, Rodney Ellis

Research output: Contribution to journal › Review article › peer-review

16 Scopus citations

Abstract

Aim: This systematic review summarizes the clinical data on focal therapy (FT) when used alone as definitive therapy for primary prostate cancer (PCA). Methods: The protocol is detailed in the online PROSPERO database, registration No. CRD42014014765. Articles evaluating any form of FT alone as a definitive treatment for PCA in adult male patients were included. Results: Of 10,419 identified articles, 10,401 were excluded, and thus leaving 18 for analysis. In total, 2288 patients were treated using seven modalities. The outcomes of FT in PCA seem to be similar to those observed with whole gland therapy and with fewer side effects. Conclusion: Further research, including prospective randomized trials, is warranted to elucidate the potential advantages of focal radiation techniques for treating PCA.

Original language	English (US)
Pages (from-to)	649-663
Number of pages	15
Journal	Future Oncology
Volume	13
Issue number	7
DOIs	https://doi.org/10.2217/fon-2016-0354
State	Published - Mar 2017

All Science Journal Classification (ASJC) codes

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.2217/fon-2016-0354

Cite this

@article{83209e805242482c9d475d3b166e4741,

title = "Outcomes and toxicities in patients treated with definitive focal therapy for primary prostate cancer: Systematic review",

abstract = "Aim: This systematic review summarizes the clinical data on focal therapy (FT) when used alone as definitive therapy for primary prostate cancer (PCA). Methods: The protocol is detailed in the online PROSPERO database, registration No. CRD42014014765. Articles evaluating any form of FT alone as a definitive treatment for PCA in adult male patients were included. Results: Of 10,419 identified articles, 10,401 were excluded, and thus leaving 18 for analysis. In total, 2288 patients were treated using seven modalities. The outcomes of FT in PCA seem to be similar to those observed with whole gland therapy and with fewer side effects. Conclusion: Further research, including prospective randomized trials, is warranted to elucidate the potential advantages of focal radiation techniques for treating PCA.",

author = "Atallah Baydoun and Bryan Traughber and Nathan Morris and {Abi Zeid Daou}, Michella and Michael McGraw and Podder, {Tarun K.} and Muzic, {Raymond F.} and Lo, {Simon S.} and Ponsky, {Lee E.} and Mitchell MacHtay and Rodney Ellis",

note = "Publisher Copyright: {\textcopyright} 2016 Future Medicine Ltd.",

year = "2017",

month = mar,

doi = "10.2217/fon-2016-0354",

language = "English (US)",

volume = "13",

pages = "649--663",

journal = "Future Oncology",

issn = "1479-6694",

publisher = "Taylor and Francis Ltd.",

number = "7",

}

TY - JOUR

T1 - Outcomes and toxicities in patients treated with definitive focal therapy for primary prostate cancer

T2 - Systematic review

AU - Baydoun, Atallah

AU - Traughber, Bryan

AU - Morris, Nathan

AU - Abi Zeid Daou, Michella

AU - McGraw, Michael

AU - Podder, Tarun K.

AU - Muzic, Raymond F.

AU - Lo, Simon S.

AU - Ponsky, Lee E.

AU - MacHtay, Mitchell

AU - Ellis, Rodney

PY - 2017/3

Y1 - 2017/3

N2 - Aim: This systematic review summarizes the clinical data on focal therapy (FT) when used alone as definitive therapy for primary prostate cancer (PCA). Methods: The protocol is detailed in the online PROSPERO database, registration No. CRD42014014765. Articles evaluating any form of FT alone as a definitive treatment for PCA in adult male patients were included. Results: Of 10,419 identified articles, 10,401 were excluded, and thus leaving 18 for analysis. In total, 2288 patients were treated using seven modalities. The outcomes of FT in PCA seem to be similar to those observed with whole gland therapy and with fewer side effects. Conclusion: Further research, including prospective randomized trials, is warranted to elucidate the potential advantages of focal radiation techniques for treating PCA.

AB - Aim: This systematic review summarizes the clinical data on focal therapy (FT) when used alone as definitive therapy for primary prostate cancer (PCA). Methods: The protocol is detailed in the online PROSPERO database, registration No. CRD42014014765. Articles evaluating any form of FT alone as a definitive treatment for PCA in adult male patients were included. Results: Of 10,419 identified articles, 10,401 were excluded, and thus leaving 18 for analysis. In total, 2288 patients were treated using seven modalities. The outcomes of FT in PCA seem to be similar to those observed with whole gland therapy and with fewer side effects. Conclusion: Further research, including prospective randomized trials, is warranted to elucidate the potential advantages of focal radiation techniques for treating PCA.

UR - http://www.scopus.com/inward/record.url?scp=85012048719&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85012048719&partnerID=8YFLogxK

U2 - 10.2217/fon-2016-0354

DO - 10.2217/fon-2016-0354

M3 - Review article

C2 - 27809594

AN - SCOPUS:85012048719

SN - 1479-6694

VL - 13

SP - 649

EP - 663

JO - Future Oncology

JF - Future Oncology

IS - 7

ER -

Outcomes and toxicities in patients treated with definitive focal therapy for primary prostate cancer: Systematic review

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this