TY - JOUR
T1 - Over-the-Counter Alkali Agents to Raise Urine pH and Citrate Excretion
T2 - A Prospective Crossover Study in Healthy Adults
AU - Canvasser, Noah E.
AU - Rivera, Marcelino
AU - Bechis, Seth K.
AU - Ingimarsson, Johann
AU - Knoedler, John
AU - Stern, Karen
AU - Stoughton, Christa L.
AU - Wollin, Daniel
AU - Borofsky, Michael
AU - Bhojani, Naeem
AU - Tayeb, Marawan El
AU - Kamphuis, Guido
AU - Leavitt, David
AU - Hsi, Ryan S.
AU - Scotland, Kymora B.
N1 - Funding Information:
Source of funding: This was an investigator-initiated project where the protocol, data collection, statistical analysis and drafting of the manuscript was performed by the authors. The study supplements, Litholyte and KSPtabs, and 24 hour urine testing were funded by the manufacturers.
Publisher Copyright:
© 2022 Elsevier Inc.
PY - 2022/10
Y1 - 2022/10
N2 - Objective: To assess the effect of 2 over-the-counter alkalizing agents on 24 hour urinary parameters. Materials and Methods: Ten healthy volunteers without a history of kidney stones were recruited to complete a baseline 24 hour urinalysis with a 4 day diet inventory. Participants then maintained the same diet on either LithoLyte (20 mEq 2 times per day) or KSPtabs (1 tablet 2 times per day) and submitted another 24 hour urinalysis. The process was repeated with the other supplement. Urinary alkali parameters were compared to baseline, and side effects were elicited with a questionnaire. Results: LithoLyte intake resulted in a non-significant increase in citrate (597-758 mg/day, P =.058, an increase in urine pH (6.46-6.66, P =.028), and a decrease in urine ammonium (41-36 mmol/day, P =.005) compared to baseline. KSPtabs resulted in an increase in citrate (597-797 mg/day, P =.037) and urine pH (6.46-6.86, P =.037), with a non-significant decrease in ammonium (41-34 mmol/day, P =.059). No significant differences were seen comparing urinary analytes between LithoLyte and KSPtabs. With Litholyte, no side effects, mild, moderate, and severe side effects were seen in 50%, 40%, 10%, and 0%, respectively. With KSPtabs, rates were 60%, 20%, 10%, and 10%, respectively. Conclusion: In healthy participants without a history of kidney stones, LithoLyte and KSPtabs are effective over-the-counter alkali supplements, with a similar side effect profile to prescription potassium citrate.
AB - Objective: To assess the effect of 2 over-the-counter alkalizing agents on 24 hour urinary parameters. Materials and Methods: Ten healthy volunteers without a history of kidney stones were recruited to complete a baseline 24 hour urinalysis with a 4 day diet inventory. Participants then maintained the same diet on either LithoLyte (20 mEq 2 times per day) or KSPtabs (1 tablet 2 times per day) and submitted another 24 hour urinalysis. The process was repeated with the other supplement. Urinary alkali parameters were compared to baseline, and side effects were elicited with a questionnaire. Results: LithoLyte intake resulted in a non-significant increase in citrate (597-758 mg/day, P =.058, an increase in urine pH (6.46-6.66, P =.028), and a decrease in urine ammonium (41-36 mmol/day, P =.005) compared to baseline. KSPtabs resulted in an increase in citrate (597-797 mg/day, P =.037) and urine pH (6.46-6.86, P =.037), with a non-significant decrease in ammonium (41-34 mmol/day, P =.059). No significant differences were seen comparing urinary analytes between LithoLyte and KSPtabs. With Litholyte, no side effects, mild, moderate, and severe side effects were seen in 50%, 40%, 10%, and 0%, respectively. With KSPtabs, rates were 60%, 20%, 10%, and 10%, respectively. Conclusion: In healthy participants without a history of kidney stones, LithoLyte and KSPtabs are effective over-the-counter alkali supplements, with a similar side effect profile to prescription potassium citrate.
UR - https://www.scopus.com/pages/publications/85136720737
UR - https://www.scopus.com/pages/publications/85136720737#tab=citedBy
U2 - 10.1016/j.urology.2022.05.049
DO - 10.1016/j.urology.2022.05.049
M3 - Article
C2 - 35843354
AN - SCOPUS:85136720737
SN - 0090-4295
VL - 168
SP - 72
EP - 78
JO - Urology
JF - Urology
ER -