Overcoming Resistance to Drugs Targeting KRASG12C Mutation

Delong Jiao, Shengyu Yang

Research output: Contribution to journalReview articlepeer-review

53 Scopus citations

Abstract

Activating KRAS mutations are present in 25% of human cancer. Although oncogenic Ras was deemed “undruggable” in the past, recent efforts led to the development of pharmacological inhibitors targeting the KRASG12C mutant, which have shown promise in early clinical trials. The development of allele-specific K-RasG12C inhibitors marked a new chapter in targeting oncogenic KRAS mutant in cancer. However, drug resistance against these new drugs will likely limit their efficacy in the clinic. Genome-wide approaches have been used to interrogate the mechanisms of resistance to K-RasG12C inhibitors, which would facilitate the development of therapeutics overcoming drug resistance. This article reviews the latest progress in resistance to K-RasG12C-targeted therapies and aims to provide insight in future research targeting drug resistance in cancer.

Original languageEnglish (US)
Article number100035
JournalInnovation
Volume1
Issue number2
DOIs
StatePublished - Aug 28 2020

All Science Journal Classification (ASJC) codes

  • General

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