Overshoot of oxygen pressure in post-hypoxic brain tissue: a re-evaluation

Steven J. Schiff, George G. Somjen

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


Tissue oxygen pressure (ptO2) was measured with noble metal microelectrodes in hippocampal slices in vitro. During hypoxia, the ptO2 at 100 μm depth fell rapidly to less than 20 mm Hg. During reoxygenation, large transient ptO2 increases above normoxic values were observed. These data demonstrate that ptO2 'overshoots' occur independently of in situ posthypoxic hyperemia and may reflect pathologic chemical reactions in brain tissue during reoxygenation.

Original languageEnglish (US)
Pages (from-to)150-153
Number of pages4
JournalBrain research
Issue number1
StatePublished - Sep 30 1985

All Science Journal Classification (ASJC) codes

  • General Neuroscience
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology


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