Palladium-catalyzed asymmetric iodination of unactivated C-H bonds under mild conditions

Ramesh Giri, Xiao Chen, Jin Quan Yu

Research output: Contribution to journalArticlepeer-review

454 Scopus citations


(Chemical Equation Presented) Specific, asymmetric, and mild: Oxazoline (Oxa), a removable chelating chiral auxiliary, assists in the asymmetric activation of C(sp3)-H bonds at the β position and C(sp 2)-H bonds at the γ position. Pd-(OAc)2 is an effective catalyst for the selective and asymmetric iodination of methyl, cyclopropyl, and aryl groups at room temperature (see formulae).

Original languageEnglish (US)
Pages (from-to)2112-2115
Number of pages4
JournalAngewandte Chemie - International Edition
Issue number14
StatePublished - Mar 29 2005

All Science Journal Classification (ASJC) codes

  • Catalysis
  • General Chemistry


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