A PdII-catalyzed ortho-(Csp2)–H arylation reaction of benzaldehydes using a catalytic amount of 2-(methylsulfinyl)aniline as transient auxiliary was developed. This reaction is compatible with a broad range of benzaldehyde and aryl iodide substrates. Compared with other related reaction systems, an excellent regioselectivity for ortho-C(sp2)−H bonds over benzylic C(sp3)−H bonds was obtained for ortho-alkyl-benzaldehyde substrates.
All Science Journal Classification (ASJC) codes
- Organic Chemistry