TY - JOUR
T1 - Palliative treatment of poor prognosis patients with malignant gliomas
AU - Hadziahmetovic, Mersiha
AU - Lo, Simon S.
AU - Clarke, James W.
AU - Farace, Elana
AU - Cavaliere, Robert
PY - 2008/1
Y1 - 2008/1
N2 - High-grade gliomas are the most commonly diagnosed malignant brain tumor in adults. Prognosis can be estimated by examining risk factors, including histology, age and performance status. Postoperative radiation therapy is associated with improved survival and standard treatment includes external beam radiotherapy to a dose of 60 Gy in 30-33 fractions. Patients with poor prognostic features have a more limited benefit from radiotherapy. This article reviews the current state of knowledge on risk stratification and analyzes strategies that can be employed to better individualize treatment for poor-prognosis patients.
AB - High-grade gliomas are the most commonly diagnosed malignant brain tumor in adults. Prognosis can be estimated by examining risk factors, including histology, age and performance status. Postoperative radiation therapy is associated with improved survival and standard treatment includes external beam radiotherapy to a dose of 60 Gy in 30-33 fractions. Patients with poor prognostic features have a more limited benefit from radiotherapy. This article reviews the current state of knowledge on risk stratification and analyzes strategies that can be employed to better individualize treatment for poor-prognosis patients.
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U2 - 10.1586/14737140.8.1.125
DO - 10.1586/14737140.8.1.125
M3 - Review article
C2 - 18095889
AN - SCOPUS:38349044628
SN - 1473-7140
VL - 8
SP - 125
EP - 132
JO - Expert Review of Anticancer Therapy
JF - Expert Review of Anticancer Therapy
IS - 1
ER -