TY - JOUR
T1 - Papillomavirus infectious pathways
T2 - A comparison of systems
AU - Biryukov, Jennifer
AU - Meyers, Craig
N1 - Publisher Copyright:
© 2015 by the author; licensee MDPI, Basel, Switzerland.
PY - 2015/8/4
Y1 - 2015/8/4
N2 - The HPV viral lifecycle is tightly linked to the host cell differentiation, causing difficulty in growing virions in culture. A system that bypasses the need for differentiating epithelium has allowed for generation of recombinant particles, such as virus-like particles (VLPs), pseudovirions (PsV), and quasivirions (QV). Much of the research looking at the HPV life cycle, infectivity, and structure has been generated utilizing recombinant particles. While recombinant particles have proven to be invaluable, allowing for a rapid progression of the HPV field, there are some significant differences between recombinant particles and native virions and very few comparative studies using native virions to confirm results are done. This review serves to address the conflicting data in the HPV field regarding native virions and recombinant particles.
AB - The HPV viral lifecycle is tightly linked to the host cell differentiation, causing difficulty in growing virions in culture. A system that bypasses the need for differentiating epithelium has allowed for generation of recombinant particles, such as virus-like particles (VLPs), pseudovirions (PsV), and quasivirions (QV). Much of the research looking at the HPV life cycle, infectivity, and structure has been generated utilizing recombinant particles. While recombinant particles have proven to be invaluable, allowing for a rapid progression of the HPV field, there are some significant differences between recombinant particles and native virions and very few comparative studies using native virions to confirm results are done. This review serves to address the conflicting data in the HPV field regarding native virions and recombinant particles.
UR - http://www.scopus.com/inward/record.url?scp=84941039850&partnerID=8YFLogxK
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U2 - 10.3390/v7082823
DO - 10.3390/v7082823
M3 - Review article
C2 - 26247955
AN - SCOPUS:84941039850
SN - 1999-4915
VL - 7
SP - 4303
EP - 4325
JO - Viruses
JF - Viruses
IS - 8
ER -