TY - JOUR
T1 - Parathyroid hormone-related protein
T2 - a developmental regulatory molecule necessary for mammary gland development.
AU - Dunbar, M. E.
AU - Wysolmerski, J. J.
N1 - Funding Information:
The authors would like to thank Drs. William Philbrick and Karl Insogna for sharing unpublished data and for their helpful discussions. We would also like to thank Dr. Arthur Broadus for his critical reading of this manuscript. Wok bryJ. J. Wysolmerski was supported by the DOD grant DAMD17-96-6198 and NIH grant CA 60498. M.E. Dunbar received support from the DOD postdoctoral fellowship DAMD17-97-7137.
PY - 1999/1
Y1 - 1999/1
N2 - Parathyroid hormone-related protein (PTHrP) was originally identified as the tumor factor responsible for a clinical syndrome known as humoral hypercalcemia of malignancy. It is now appreciated that PTHrP3 is a developmental regulatory molecule expressed during the formation of a wide variety of organs. Recently, our laboratory has demonstrated that PTHrP is necessary for mammary gland development. Our studies have suggested that this molecule participates in the regulation of epithelial-mesenchymal interactions during embryonic mammary development and perhaps also during adolescent ductal morphogenesis. In addition, it has been suggested that PTHrP plays a critical role in the establishment of bone metastases in breast cancer. In this article, we will discuss the current knowledge of the mechanisms underlying PTHrPs actions during normal mammary development and in breast cancer.
AB - Parathyroid hormone-related protein (PTHrP) was originally identified as the tumor factor responsible for a clinical syndrome known as humoral hypercalcemia of malignancy. It is now appreciated that PTHrP3 is a developmental regulatory molecule expressed during the formation of a wide variety of organs. Recently, our laboratory has demonstrated that PTHrP is necessary for mammary gland development. Our studies have suggested that this molecule participates in the regulation of epithelial-mesenchymal interactions during embryonic mammary development and perhaps also during adolescent ductal morphogenesis. In addition, it has been suggested that PTHrP plays a critical role in the establishment of bone metastases in breast cancer. In this article, we will discuss the current knowledge of the mechanisms underlying PTHrPs actions during normal mammary development and in breast cancer.
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U2 - 10.1023/A:1018700502518
DO - 10.1023/A:1018700502518
M3 - Review article
C2 - 10219904
AN - SCOPUS:0032609185
SN - 1083-3021
VL - 4
SP - 21
EP - 34
JO - Journal of mammary gland biology and neoplasia
JF - Journal of mammary gland biology and neoplasia
IS - 1
ER -
