Parathyroid hormone-related protein: a developmental regulatory molecule necessary for mammary gland development.

M. E. Dunbar; J. J. Wysolmerski

doi:10.1023/A:1018700502518

Parathyroid hormone-related protein: a developmental regulatory molecule necessary for mammary gland development.

M. E. Dunbar, J. J. Wysolmerski

Division of Science (Berks)

Research output: Contribution to journal › Review article › peer-review

61 Scopus citations

Abstract

Parathyroid hormone-related protein (PTHrP) was originally identified as the tumor factor responsible for a clinical syndrome known as humoral hypercalcemia of malignancy. It is now appreciated that PTHrP3 is a developmental regulatory molecule expressed during the formation of a wide variety of organs. Recently, our laboratory has demonstrated that PTHrP is necessary for mammary gland development. Our studies have suggested that this molecule participates in the regulation of epithelial-mesenchymal interactions during embryonic mammary development and perhaps also during adolescent ductal morphogenesis. In addition, it has been suggested that PTHrP plays a critical role in the establishment of bone metastases in breast cancer. In this article, we will discuss the current knowledge of the mechanisms underlying PTHrPs actions during normal mammary development and in breast cancer.

Original language	English (US)
Pages (from-to)	21-34
Number of pages	14
Journal	Journal of mammary gland biology and neoplasia
Volume	4
Issue number	1
DOIs	https://doi.org/10.1023/A:1018700502518
State	Published - Jan 1999

All Science Journal Classification (ASJC) codes

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1023/A:1018700502518

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@article{e7bae384fc474a8bae73c2110270f353,

title = "Parathyroid hormone-related protein: a developmental regulatory molecule necessary for mammary gland development.",

abstract = "Parathyroid hormone-related protein (PTHrP) was originally identified as the tumor factor responsible for a clinical syndrome known as humoral hypercalcemia of malignancy. It is now appreciated that PTHrP3 is a developmental regulatory molecule expressed during the formation of a wide variety of organs. Recently, our laboratory has demonstrated that PTHrP is necessary for mammary gland development. Our studies have suggested that this molecule participates in the regulation of epithelial-mesenchymal interactions during embryonic mammary development and perhaps also during adolescent ductal morphogenesis. In addition, it has been suggested that PTHrP plays a critical role in the establishment of bone metastases in breast cancer. In this article, we will discuss the current knowledge of the mechanisms underlying PTHrPs actions during normal mammary development and in breast cancer.",

author = "Dunbar, {M. E.} and Wysolmerski, {J. J.}",

note = "Funding Information: The authors would like to thank Drs. William Philbrick and Karl Insogna for sharing unpublished data and for their helpful discussions. We would also like to thank Dr. Arthur Broadus for his critical reading of this manuscript. Wok bryJ. J. Wysolmerski was supported by the DOD grant DAMD17-96-6198 and NIH grant CA 60498. M.E. Dunbar received support from the DOD postdoctoral fellowship DAMD17-97-7137.",

year = "1999",

month = jan,

doi = "10.1023/A:1018700502518",

language = "English (US)",

volume = "4",

pages = "21--34",

journal = "Journal of mammary gland biology and neoplasia",

issn = "1083-3021",

publisher = "Springer New York",

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T1 - Parathyroid hormone-related protein

T2 - a developmental regulatory molecule necessary for mammary gland development.

AU - Dunbar, M. E.

AU - Wysolmerski, J. J.

N1 - Funding Information: The authors would like to thank Drs. William Philbrick and Karl Insogna for sharing unpublished data and for their helpful discussions. We would also like to thank Dr. Arthur Broadus for his critical reading of this manuscript. Wok bryJ. J. Wysolmerski was supported by the DOD grant DAMD17-96-6198 and NIH grant CA 60498. M.E. Dunbar received support from the DOD postdoctoral fellowship DAMD17-97-7137.

PY - 1999/1

Y1 - 1999/1

N2 - Parathyroid hormone-related protein (PTHrP) was originally identified as the tumor factor responsible for a clinical syndrome known as humoral hypercalcemia of malignancy. It is now appreciated that PTHrP3 is a developmental regulatory molecule expressed during the formation of a wide variety of organs. Recently, our laboratory has demonstrated that PTHrP is necessary for mammary gland development. Our studies have suggested that this molecule participates in the regulation of epithelial-mesenchymal interactions during embryonic mammary development and perhaps also during adolescent ductal morphogenesis. In addition, it has been suggested that PTHrP plays a critical role in the establishment of bone metastases in breast cancer. In this article, we will discuss the current knowledge of the mechanisms underlying PTHrPs actions during normal mammary development and in breast cancer.

AB - Parathyroid hormone-related protein (PTHrP) was originally identified as the tumor factor responsible for a clinical syndrome known as humoral hypercalcemia of malignancy. It is now appreciated that PTHrP3 is a developmental regulatory molecule expressed during the formation of a wide variety of organs. Recently, our laboratory has demonstrated that PTHrP is necessary for mammary gland development. Our studies have suggested that this molecule participates in the regulation of epithelial-mesenchymal interactions during embryonic mammary development and perhaps also during adolescent ductal morphogenesis. In addition, it has been suggested that PTHrP plays a critical role in the establishment of bone metastases in breast cancer. In this article, we will discuss the current knowledge of the mechanisms underlying PTHrPs actions during normal mammary development and in breast cancer.

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SN - 1083-3021

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JF - Journal of mammary gland biology and neoplasia

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ER -

Parathyroid hormone-related protein: a developmental regulatory molecule necessary for mammary gland development.

Abstract

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