Abstract
Objective: The objective of this study was to determine the safety and efficacy of botulinum toxin A in ameliorating refractory sialorrhea and improving quality of life in patients with amyotrophic lateral sclerosis. Materials and Methods: Six patients with bulbar ALS received bilateral parotid gland injections of botulinum toxin A. Results: No adverse effects occurred. Tissue use decreased in 5 of 7 patients at a dose of 10 units and in 3 of 4 patients at a dose of 20 units. Self-reported quality of life did not change in most. Conclusions: Parotid gland injections of botulinum toxin appear safe and may be helpful in some patients with ALS for the treatment of sialorrhea.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 62-65 |
| Number of pages | 4 |
| Journal | Journal of clinical neuromuscular disease |
| Volume | 7 |
| Issue number | 2 |
| DOIs | |
| State | Published - Dec 2005 |
All Science Journal Classification (ASJC) codes
- Neurology
- Clinical Neurology
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