TY - JOUR
T1 - Particulate matter and albuminuria, glomerular filtration rate, and incident ckd
AU - Blum, Matthew F.
AU - Surapaneni, Aditya
AU - Stewart, James D.
AU - Liao, Duanping
AU - Yanosky, Jeff D.
AU - Whitsel, Eric A.
AU - Power, Melinda C.
AU - Grams, Morgan E.
N1 - Funding Information:
The Atherosclerosis Risk in Communities study has been funded in whole or in part by the National Heart, Lung, and Blood Institute; National Institutes of Health (NIH); US Department of Health and Human Services federal grants HHSN268201700001I, HHSN268201700002I, HHSN268201700003I, HHSN268201700005I, and HHSN268201700004I. Funding for laboratory testing and bio-specimen collection at Atherosclerosis Risk in Communities visit 6 was supported by NIDDK grant R01DK089174. Dr. Grams is sup-portedbyNIDDKgrant5R01DK115534.Dr.Yanoskyissupportedby NIH grant R01ES020836-02 (PI: Dr. Whitsel).
Funding Information:
Dr. Grams reports receiving nonfinancial travel support from Dialysis Clinic, Inc. and Kidney Disease Improving Global Outcomes as well as grants from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) and the National Kidney Foundation, outside of the submitted work. Dr. Blum, Dr. Liao, Dr. Power, Mr. Stewart, Dr. Surapaneni, Dr. Whitsel, and Dr. Yanosky have nothing to disclose.
Funding Information:
The Atherosclerosis Risk in Communities study has been funded in whole or in part by the National Heart, Lung, and Blood Institute; National Institutes of Health (NIH); US Department of Health and Human Services federal grants HHSN268201700001I, HHSN268201700002I, HHSN268201700003I, HHSN268201700005I, and HHSN268201700004I. Funding for laboratory testing and bio-specimen collection at Atherosclerosis Risk in Communities visit 6 was supported by NIDDK grant R01DK089174. Dr. Grams is sup-portedbyNIDDKgrant 5R01DK115534. Dr. Yanoskyis supportedby NIH grant R01ES020836-02 (PI: Dr. Whitsel).
Publisher Copyright:
© 2020, American Society of Nephrology. All rights reserved.
PY - 2020/3/6
Y1 - 2020/3/6
N2 - Background and objectives Exposure to particulate matter (PM),2.5 mm in aerodynamic diameter (PM2.5) has been linked to detrimental health effects. This study aimed to describe the relationship between long-term PM2.5 exposure and kidney disease, including eGFR, level of albuminuria, and incident CKD. Design, setting, participants, & measurements The study included 10,997 participants from the Atherosclerosis Risk in Communities cohort who were followed from 1996–1998 through 2016. Monthly mean PM2.5 concentrations (mg/m3 ) were estimated at geocoded participant addresses using geographic information system–based, spatiotemporal generalized additive mixed models—including geospatial covariates such as land use—and then averaged over the 12-month period preceding participant examination. Covariate-adjusted, cross-sectional associations of PM2.5, baseline eGFR, and urinary albumin-creatinine ratio (UACR) were estimated using linear regression. PM2.5 and incident CKD (defined as follow-up eGFR,60 ml/min per 1.73 m2 with $25% eGFR decline relative to baseline, CKD-related hospitalization or death based on International Classification of Diseases 9/10 codes, or development of ESKD) associations were estimated using Cox proportional hazards regression. Modeling was stratified by study site, and stratum-specific estimates were combined using random-effects meta-analyses. Results Baseline mean participant age was 63 (66) years and eGFR was 86 (616) ml/min per 1.73 m2. There was no significant PM2.5-eGFR association at baseline. Each 1-mg/m3 higher annual average PM2.5 was associated with higher UACR after adjusting for demographics, socioeconomic status, and clinical covariates (percentage difference, 6.6%; 95% confidence interval [95% CI], 2.6% to 10.7%). Each 1-mg/m3 higher annual average PM2.5 was associated with a significantly higher risk of incident CKD (hazard ratio, 1.05; 95% CI, 1.01 to 1.10). Conclusions Exposure to higher annual average PM2.5 concentrations was associated with a higher level of albuminuria and higher risk for incident CKD in a community-based cohort.
AB - Background and objectives Exposure to particulate matter (PM),2.5 mm in aerodynamic diameter (PM2.5) has been linked to detrimental health effects. This study aimed to describe the relationship between long-term PM2.5 exposure and kidney disease, including eGFR, level of albuminuria, and incident CKD. Design, setting, participants, & measurements The study included 10,997 participants from the Atherosclerosis Risk in Communities cohort who were followed from 1996–1998 through 2016. Monthly mean PM2.5 concentrations (mg/m3 ) were estimated at geocoded participant addresses using geographic information system–based, spatiotemporal generalized additive mixed models—including geospatial covariates such as land use—and then averaged over the 12-month period preceding participant examination. Covariate-adjusted, cross-sectional associations of PM2.5, baseline eGFR, and urinary albumin-creatinine ratio (UACR) were estimated using linear regression. PM2.5 and incident CKD (defined as follow-up eGFR,60 ml/min per 1.73 m2 with $25% eGFR decline relative to baseline, CKD-related hospitalization or death based on International Classification of Diseases 9/10 codes, or development of ESKD) associations were estimated using Cox proportional hazards regression. Modeling was stratified by study site, and stratum-specific estimates were combined using random-effects meta-analyses. Results Baseline mean participant age was 63 (66) years and eGFR was 86 (616) ml/min per 1.73 m2. There was no significant PM2.5-eGFR association at baseline. Each 1-mg/m3 higher annual average PM2.5 was associated with higher UACR after adjusting for demographics, socioeconomic status, and clinical covariates (percentage difference, 6.6%; 95% confidence interval [95% CI], 2.6% to 10.7%). Each 1-mg/m3 higher annual average PM2.5 was associated with a significantly higher risk of incident CKD (hazard ratio, 1.05; 95% CI, 1.01 to 1.10). Conclusions Exposure to higher annual average PM2.5 concentrations was associated with a higher level of albuminuria and higher risk for incident CKD in a community-based cohort.
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U2 - 10.2215/CJN.08350719
DO - 10.2215/CJN.08350719
M3 - Article
C2 - 32108020
AN - SCOPUS:85081661263
SN - 1555-9041
VL - 15
SP - 311
EP - 319
JO - Clinical Journal of the American Society of Nephrology
JF - Clinical Journal of the American Society of Nephrology
IS - 3
ER -