Passive deformation analysis of human leukocytes

Cheng Dong, R. Skalak, Kuo Li Paul Sung, G. W. Schmid-Schönbein, Shu Chien

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164 Scopus citations


The following analysis presents an experimental and theoretical study of the passive viscoelastic behavior of human leukocytes. Individual neutrophils in EDTA were observed both during their partial aspiration into a small micropipette and after expulsion from a large micropipette where the cell had been totally aspirated and deformed into a sausage shape. To analyze the data, a passive model of leukocyte rheology has been developed consisting of a cortical shell containing a Maxwell fluid which describes the average properties of the cell cytoplasm. The cortical shell represents a crosslinked actin layer near the surface of the cell and is assumed to be under pre-stressed tension. This model can reproduce the results of experiments using micropipette for both short-time small deformation and slow recovery data after large deformation. In addition, a finite element scheme has been established for the same model which shows close agreement with the analytical solution.

Original languageEnglish (US)
Pages (from-to)27-36
Number of pages10
JournalJournal of Biomechanical Engineering
Issue number1
StatePublished - Feb 1988

All Science Journal Classification (ASJC) codes

  • Biomedical Engineering
  • Physiology (medical)


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