TY - JOUR
T1 - Pathogenomic analysis of the common bovine Staphylococcus aureus clone (ET3)
T2 - Emergence of a virulent subtype with potential risk to public health
AU - Guinane, Caitriona M.
AU - Sturdevant, Daniel E.
AU - Herron-Olson, Lisa
AU - Otto, Michael
AU - Smyth, Davida S.
AU - Villaruz, Amer E.
AU - Kapur, Vivek
AU - Hartigan, Patrick J.
AU - Smyth, Cyril J.
AU - Fitzgerald, J. Ross
N1 - Funding Information:
Received 2 May 2007; accepted 19 July 2007; electronically published XX December 2007. Potential conflicts of interest: none reported. Financial support: Biotechnology and Biological Sciences Research Council (grant BB/D521222/1 to J.R.F.); Teagasc, the Irish Agriculture and Food Development Authority. a Present affiliation: Department of Microbiology and Immunology, Basic Sciences Building, New York Medical College, Valhalla, New York. Reprints or correspondence: Dr. Ross Fitzgerald, Centre for Infectious Diseases, The Chancellor’s Bldg., New Royal Infirmary, University of Edinburgh, Edinburgh EH16 4SB, Scotland, United Kingdom ([email protected]).
PY - 2008/1/15
Y1 - 2008/1/15
N2 - A common clone (ET3) of Staphylococcus aureus is responsible for a large proportion of cases of bovine mastitis and occasionally causes zoonotic infections of humans. In the present study, we report the identification of a virulent clonal subtype (ST151) of ET3, which resulted in increased tissue damage and mortality in a mouse model of mastitis. ST151 has undergone extensive diversification in virulence and regulatory-gene content, including the acquisition of genetic elements encoding toxins not made by other ET3 strains. Furthermore, ST151 had elevated levels of RNAIII and cytolytic toxin- gene expression, consistent with the enhanced virulence observed during experimental infection. Previously, the ST151 clone was shown to be hypersusceptible to the acquisition of vancomycin-resistance genes from Enterococcus spp. Taken together, these data indicate the emergence of a virulent subtype of the common ET3 clone, which could present an enhanced risk to public health.
AB - A common clone (ET3) of Staphylococcus aureus is responsible for a large proportion of cases of bovine mastitis and occasionally causes zoonotic infections of humans. In the present study, we report the identification of a virulent clonal subtype (ST151) of ET3, which resulted in increased tissue damage and mortality in a mouse model of mastitis. ST151 has undergone extensive diversification in virulence and regulatory-gene content, including the acquisition of genetic elements encoding toxins not made by other ET3 strains. Furthermore, ST151 had elevated levels of RNAIII and cytolytic toxin- gene expression, consistent with the enhanced virulence observed during experimental infection. Previously, the ST151 clone was shown to be hypersusceptible to the acquisition of vancomycin-resistance genes from Enterococcus spp. Taken together, these data indicate the emergence of a virulent subtype of the common ET3 clone, which could present an enhanced risk to public health.
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U2 - 10.1086/524689
DO - 10.1086/524689
M3 - Article
C2 - 18177250
AN - SCOPUS:39149114754
SN - 0022-1899
VL - 197
SP - 205
EP - 213
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 2
ER -