TY - JOUR
T1 - Pathologic sequelae of allosensitization in liver transplantation
AU - Zimmerman, Michael A.
AU - Schiller, Jennifer
AU - Kim, Joohyun
AU - Martin, Alicia
AU - Selim, Motaz
AU - Nydam, Trevor L.
AU - Cronin, David
AU - Hong, Johnny C.
N1 - Publisher Copyright:
© 2016 Elsevier Inc. All rights reserved.
PY - 2015/3/3
Y1 - 2015/3/3
N2 - The long-term impact of allosensitization between ABO compatible donor/recipient pairs in liver transplantation is unclear. Accumulating clinical evidence suggests that donor-specific antibody formation may lead to antibody-mediated rejection and is causally linked to pathologic injury, graft loss, and death. Although this immune-mediated graft dysfunction is increasingly being associated with poor outcomes, the specific pathologic sequelae are not defined. Herein, we examine the relationship between allosensitization, antibody-mediated rejection, and subsequent graft pathology.
AB - The long-term impact of allosensitization between ABO compatible donor/recipient pairs in liver transplantation is unclear. Accumulating clinical evidence suggests that donor-specific antibody formation may lead to antibody-mediated rejection and is causally linked to pathologic injury, graft loss, and death. Although this immune-mediated graft dysfunction is increasingly being associated with poor outcomes, the specific pathologic sequelae are not defined. Herein, we examine the relationship between allosensitization, antibody-mediated rejection, and subsequent graft pathology.
UR - https://www.scopus.com/pages/publications/84938630209
UR - https://www.scopus.com/pages/publications/84938630209#tab=citedBy
U2 - 10.1016/j.jss.2015.06.047
DO - 10.1016/j.jss.2015.06.047
M3 - Review article
C2 - 26253457
AN - SCOPUS:84938630209
SN - 0022-4804
VL - 200
SP - 195
EP - 199
JO - Journal of Surgical Research
JF - Journal of Surgical Research
IS - 1
ER -