Pathologic sequelae of allosensitization in liver transplantation

Michael A. Zimmerman; Jennifer Schiller; Joohyun Kim; Alicia Martin; Motaz Selim; Trevor L. Nydam; David Cronin; Johnny C. Hong

doi:10.1016/j.jss.2015.06.047

Pathologic sequelae of allosensitization in liver transplantation

Michael A. Zimmerman
, Jennifer Schiller
, Joohyun Kim
, Alicia Martin
, Motaz Selim
, Trevor L. Nydam
, David Cronin
, Johnny C. Hong

Research output: Contribution to journal › Review article › peer-review

3 Scopus citations

Abstract

The long-term impact of allosensitization between ABO compatible donor/recipient pairs in liver transplantation is unclear. Accumulating clinical evidence suggests that donor-specific antibody formation may lead to antibody-mediated rejection and is causally linked to pathologic injury, graft loss, and death. Although this immune-mediated graft dysfunction is increasingly being associated with poor outcomes, the specific pathologic sequelae are not defined. Herein, we examine the relationship between allosensitization, antibody-mediated rejection, and subsequent graft pathology.

Original language	English (US)
Pages (from-to)	195-199
Number of pages	5
Journal	Journal of Surgical Research
Volume	200
Issue number	1
DOIs	https://doi.org/10.1016/j.jss.2015.06.047
State	Published - Mar 3 2015

All Science Journal Classification (ASJC) codes

Surgery

Access to Document

10.1016/j.jss.2015.06.047

Cite this

@article{9ceb37b5eec34d829031a2a8b820b805,

title = "Pathologic sequelae of allosensitization in liver transplantation",

abstract = "The long-term impact of allosensitization between ABO compatible donor/recipient pairs in liver transplantation is unclear. Accumulating clinical evidence suggests that donor-specific antibody formation may lead to antibody-mediated rejection and is causally linked to pathologic injury, graft loss, and death. Although this immune-mediated graft dysfunction is increasingly being associated with poor outcomes, the specific pathologic sequelae are not defined. Herein, we examine the relationship between allosensitization, antibody-mediated rejection, and subsequent graft pathology.",

author = "Zimmerman, \{Michael A.\} and Jennifer Schiller and Joohyun Kim and Alicia Martin and Motaz Selim and Nydam, \{Trevor L.\} and David Cronin and Hong, \{Johnny C.\}",

year = "2015",

month = mar,

day = "3",

doi = "10.1016/j.jss.2015.06.047",

language = "English (US)",

volume = "200",

pages = "195--199",

journal = "Journal of Surgical Research",

issn = "0022-4804",

publisher = "Academic Press Inc.",

number = "1",

}

TY - JOUR

T1 - Pathologic sequelae of allosensitization in liver transplantation

AU - Zimmerman, Michael A.

AU - Schiller, Jennifer

AU - Kim, Joohyun

AU - Martin, Alicia

AU - Selim, Motaz

AU - Nydam, Trevor L.

AU - Cronin, David

AU - Hong, Johnny C.

PY - 2015/3/3

Y1 - 2015/3/3

N2 - The long-term impact of allosensitization between ABO compatible donor/recipient pairs in liver transplantation is unclear. Accumulating clinical evidence suggests that donor-specific antibody formation may lead to antibody-mediated rejection and is causally linked to pathologic injury, graft loss, and death. Although this immune-mediated graft dysfunction is increasingly being associated with poor outcomes, the specific pathologic sequelae are not defined. Herein, we examine the relationship between allosensitization, antibody-mediated rejection, and subsequent graft pathology.

AB - The long-term impact of allosensitization between ABO compatible donor/recipient pairs in liver transplantation is unclear. Accumulating clinical evidence suggests that donor-specific antibody formation may lead to antibody-mediated rejection and is causally linked to pathologic injury, graft loss, and death. Although this immune-mediated graft dysfunction is increasingly being associated with poor outcomes, the specific pathologic sequelae are not defined. Herein, we examine the relationship between allosensitization, antibody-mediated rejection, and subsequent graft pathology.

UR - https://www.scopus.com/pages/publications/84938630209

UR - https://www.scopus.com/pages/publications/84938630209#tab=citedBy

U2 - 10.1016/j.jss.2015.06.047

DO - 10.1016/j.jss.2015.06.047

M3 - Review article

C2 - 26253457

AN - SCOPUS:84938630209

SN - 0022-4804

VL - 200

SP - 195

EP - 199

JO - Journal of Surgical Research

JF - Journal of Surgical Research

IS - 1

ER -

Pathologic sequelae of allosensitization in liver transplantation

Abstract

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this