Pathology of Pancreatic Ductal Adenocarcinoma

Xuebin Yang, Krister Jones, Guoli Chen

Research output: Chapter in Book/Report/Conference proceedingChapter


Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers despite the recent improvements in its diagnosis and management. Surgical resection remains the main therapeutic strategy upon feasibility. A careful and thorough examination of tissue specimens at macroscopic and microscopic levels in a pathology laboratory is warranted for cancer diagnosis and classification, margin status evaluation, and tumor staging. PDACs include multiple histological subtypes/variants in addition to the conventional one with shared or distinctive immunohistochemical phenotypes andmolecular bases. Cytopathology sample collection through fine-needle aspiration (FNA) with or without core needle biopsies and subsequent cytological evaluation is an extremely valuable technique widely used to diagnose and characterize the tumor with a minimal risk to patients. Identifying variable precursor lesions of PDAC is helpful in understanding tumor biology, stratifying cancer risk, and predicting prognosis.Molecular genetic profiling of the precursor lesions and invasive carcinoma has been playing a vital role in early detection and appropriate management of the tumor.

Original languageEnglish (US)
Title of host publicationHepato-Pancreato-Biliary Malignancies
Subtitle of host publicationDiagnosis and Treatment in the 21st Century
PublisherSpringer International Publishing
Number of pages35
ISBN (Electronic)9783030416836
ISBN (Print)9783030416829
StatePublished - Jan 1 2022

All Science Journal Classification (ASJC) codes

  • General Medicine


Dive into the research topics of 'Pathology of Pancreatic Ductal Adenocarcinoma'. Together they form a unique fingerprint.

Cite this