TY - JOUR
T1 - Pathophysiological basis of drug-induced dyskinesias in Parkinson's disease
AU - Deogaonkar, Milind
AU - Subramanian, Thyagarajan
PY - 2005/12/1
Y1 - 2005/12/1
N2 - Drug-induced dyskinesias (DID) represent a troublesome, dose-limiting, and common complication of long-term pharmacotherapy in Parkinson's disease (PD) patients. The pathophysiological basis and clinical nature of DID is of major interest for clinicians and neuroscientists. In this review article, we evaluate the theories of pathophysiology and molecular basis of DID, validity of various animal models used in DID related research, and electrophysiological characteristics of various basal ganglia nuclei during DID. We also discuss the relevance of various treatment strategies to the pathophysiological mechanisms.
AB - Drug-induced dyskinesias (DID) represent a troublesome, dose-limiting, and common complication of long-term pharmacotherapy in Parkinson's disease (PD) patients. The pathophysiological basis and clinical nature of DID is of major interest for clinicians and neuroscientists. In this review article, we evaluate the theories of pathophysiology and molecular basis of DID, validity of various animal models used in DID related research, and electrophysiological characteristics of various basal ganglia nuclei during DID. We also discuss the relevance of various treatment strategies to the pathophysiological mechanisms.
UR - http://www.scopus.com/inward/record.url?scp=27744564201&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=27744564201&partnerID=8YFLogxK
U2 - 10.1016/j.brainresrev.2005.05.005
DO - 10.1016/j.brainresrev.2005.05.005
M3 - Review article
C2 - 16026845
AN - SCOPUS:27744564201
SN - 0165-0173
VL - 50
SP - 156
EP - 168
JO - Brain Research Reviews
JF - Brain Research Reviews
IS - 1
ER -