TY - JOUR
T1 - Pathophysiology and disease progression of atrial fibrillation
T2 - Importance of achieving and maintaining sinus rhythm
AU - Cohen, Marc
AU - Naccarelli, Gerald
PY - 2008/8
Y1 - 2008/8
N2 - Role of Rhythm Control in Atrial Fibrillation. Atrial fibrillation (AF) is a progressive disease in which arrhythmia-induced remodeling facilitates evolution from paroxysmal AF to persistent and permanent AF. Changes in electrical, structural, and contractile properties of cardiac tissue that are thought to underlie AF maintenance and progression are reviewed. Also examined is the negative impact of AF on clinical outcomes, as well as the potential benefits of restoration and maintenance of sinus rhythm. Because of the limited efficacy and adverse effects of current antiarrhythmics, new antiarrhythmic drugs need to be developed that provide safer and more effective rhythm control in AF.
AB - Role of Rhythm Control in Atrial Fibrillation. Atrial fibrillation (AF) is a progressive disease in which arrhythmia-induced remodeling facilitates evolution from paroxysmal AF to persistent and permanent AF. Changes in electrical, structural, and contractile properties of cardiac tissue that are thought to underlie AF maintenance and progression are reviewed. Also examined is the negative impact of AF on clinical outcomes, as well as the potential benefits of restoration and maintenance of sinus rhythm. Because of the limited efficacy and adverse effects of current antiarrhythmics, new antiarrhythmic drugs need to be developed that provide safer and more effective rhythm control in AF.
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U2 - 10.1111/j.1540-8167.2008.01134.x
DO - 10.1111/j.1540-8167.2008.01134.x
M3 - Review article
C2 - 18373600
AN - SCOPUS:47849127907
SN - 1045-3873
VL - 19
SP - 885
EP - 890
JO - Journal of cardiovascular electrophysiology
JF - Journal of cardiovascular electrophysiology
IS - 8
ER -