Pathophysiology-directed therapy for acute hypoxemic respiratory failure in acute myeloid leukemia with hyperleukocytosis

Jeffrey E. Schmidt; Robert F. Tamburro; Elaine M. Sillos; D. Ashley Hill; Raul C. Ribeiro; Bassem I. Razzouk

doi:10.1097/00043426-200307000-00015

Pathophysiology-directed therapy for acute hypoxemic respiratory failure in acute myeloid leukemia with hyperleukocytosis

Jeffrey E. Schmidt, Robert F. Tamburro, Elaine M. Sillos, D. Ashley Hill, Raul C. Ribeiro, Bassem I. Razzouk

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

A 17-year-old with acute myeloid leukemia M4 and hyperleukocytosis developed fulminant hypoxemic respiratory failure at presentation. After failing to respond to conventional mechanical ventilation and leukapheresis, he was started on inhaled nitric oxide (iNO) with dramatic improvement in oxygenation. Following graduated chemotherapy, his pulmonary status again deteriorated coincident with tumor lysis. After failing to respond to increases in iNO, he was placed in prone position with immediate improvement. The patient was successfully extubated. Patients with myelomonocytic leukemias are at risk for early death due to pulmonary complications. The use of adjuvant therapies directed by specific pathophysiology might decrease this risk.

Original language	English (US)
Pages (from-to)	569-571
Number of pages	3
Journal	Journal of pediatric hematology/oncology
Volume	25
Issue number	7
DOIs	https://doi.org/10.1097/00043426-200307000-00015
State	Published - Jul 2003

All Science Journal Classification (ASJC) codes

Pediatrics, Perinatology, and Child Health
Hematology
Oncology

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10.1097/00043426-200307000-00015

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title = "Pathophysiology-directed therapy for acute hypoxemic respiratory failure in acute myeloid leukemia with hyperleukocytosis",

abstract = "A 17-year-old with acute myeloid leukemia M4 and hyperleukocytosis developed fulminant hypoxemic respiratory failure at presentation. After failing to respond to conventional mechanical ventilation and leukapheresis, he was started on inhaled nitric oxide (iNO) with dramatic improvement in oxygenation. Following graduated chemotherapy, his pulmonary status again deteriorated coincident with tumor lysis. After failing to respond to increases in iNO, he was placed in prone position with immediate improvement. The patient was successfully extubated. Patients with myelomonocytic leukemias are at risk for early death due to pulmonary complications. The use of adjuvant therapies directed by specific pathophysiology might decrease this risk.",

author = "Schmidt, {Jeffrey E.} and Tamburro, {Robert F.} and Sillos, {Elaine M.} and Hill, {D. Ashley} and Ribeiro, {Raul C.} and Razzouk, {Bassem I.}",

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AU - Schmidt, Jeffrey E.

AU - Tamburro, Robert F.

AU - Sillos, Elaine M.

AU - Hill, D. Ashley

AU - Ribeiro, Raul C.

AU - Razzouk, Bassem I.

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AB - A 17-year-old with acute myeloid leukemia M4 and hyperleukocytosis developed fulminant hypoxemic respiratory failure at presentation. After failing to respond to conventional mechanical ventilation and leukapheresis, he was started on inhaled nitric oxide (iNO) with dramatic improvement in oxygenation. Following graduated chemotherapy, his pulmonary status again deteriorated coincident with tumor lysis. After failing to respond to increases in iNO, he was placed in prone position with immediate improvement. The patient was successfully extubated. Patients with myelomonocytic leukemias are at risk for early death due to pulmonary complications. The use of adjuvant therapies directed by specific pathophysiology might decrease this risk.

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Pathophysiology-directed therapy for acute hypoxemic respiratory failure in acute myeloid leukemia with hyperleukocytosis

Abstract

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