@article{cac108d477e3426ab0b8c6052b30e526,
title = "Patients Recently Treated for B-lymphoid Malignancies Show Increased Risk of Severe COVID-19",
abstract = "Patients with B-lymphoid malignancies have been consistently identified as a population at high risk of severe COVID-19. Whether this is exclusively due to cancer-related deficits in humoral and cellular immunity, or whether risk of severe COVID-19 is increased by anticancer therapy, is uncertain. Using data derived from the COVID-19 and Cancer Consortium (CCC19), we show that patients treated for B-lymphoid malignancies have an increased risk of severe COVID-19 compared with control populations of patients with non–B-lymphoid malignancies. Among patients with B-lymphoid malignancies, those who received anticancer therapy within 12 months of COVID-19 diagnosis experienced increased COVID-19 severity compared with patients with non–recently treated B-lymphoid malignancies, after adjustment for cancer status and several other prognostic factors. Our findings suggest that patients recently treated for a B-lymphoid malignancy are at uniquely high risk for severe COVID-19.",
author = "{COVID-19 and Cancer Consortium} and Rubinstein, {Samuel M.} and Divaya Bhutani and Lynch, {Ryan C.} and Hsu, {Chih Yuan} and Yu Shyr and Shailesh Advani and Mesa, {Ruben A.} and Sanjay Mishra and Mundt, {Daniel P.} and Shah, {Dimpy P.} and Sica, {R. Alejandro} and Stockerl-Goldstein, {Keith E.} and Catherine Stratton and Matthias Weiss and Alicia Beeghly-Fadiel and Melissa Accordino and Assouline, {Sarit E.} and Joy Awosika and Ziad Bakouny and Babar Bashir and Stephanie Berg and Bilen, {Mehmet Asim} and Castellano, {Cecilia A.} and Cogan, {Jacob C.} and Devendra, {K. C.} and Friese, {Christopher R.} and Shilpa Gupta and Daniel Hausrath and Clara Hwang and Johnson, {Nathalie A.} and Monika Joshi and Anup Kasi and Klein, {Elizabeth J.} and Koshkin, {Vadim S.} and Kuderer, {Nicole M.} and Kwon, {Daniel H.} and Chris Labaki and Tahir Latif and Eric Lau and Xuanyi Li and Lyman, {Gary H.} and McKay, {Rana R.} and Gayathri Nagaraj and Amanda Nizam and Nonato, {Taylor K.} and Olszewski, {Adam J.} and Polimera, {Hyma V.} and Portuguese, {Andrew J.} and Puc, {Matthew M.} and Pedram Razavi",
note = "Publisher Copyright: {\textcopyright} 2022 American Association for Cancer Research.",
year = "2022",
month = may,
day = "1",
doi = "10.1158/2643-3230.BCD-22-0013",
language = "English (US)",
volume = "3",
pages = "181--193",
journal = "Blood cancer discovery",
issn = "2643-3230",
publisher = "NLM (Medline)",
number = "3",
}
