TY - JOUR
T1 - Patients' views on incidental findings from clinical exome sequencing
AU - Clift, Kristin E.
AU - Halverson, Colin M.E.
AU - Fiksdal, Alexander S.
AU - Kumbamu, Ashok
AU - Sharp, Richard R.
AU - McCormick, Jennifer B.
N1 - Funding Information:
We thank the study participants for their contribution. The authors are also grateful to Marguerite Robinson for the help in editing this paper, and Kari Neutzling and Rachel Topazian for their help with data analysis. The authors also thank the genetic counselors, Kiley J Johnson, Kimberly Guthrie, and Kimberly Schahl for facilitating access to patients. The authors graciously thank the Mayo Clinic’s Division of General Internal Medicine for supporting the publication fee. This study was supported by the Mayo Clinic Center for Individualized Medicine .
Publisher Copyright:
© 2015.
PY - 2015/3/1
Y1 - 2015/3/1
N2 - This article characterizes the opinions of patients and family members of patients undergoing clinical genomic-based testing regarding the return of incidental findings from these tests. Over sixteen months, we conducted 55 in-depth interviews with individuals to explore their preferences regarding which types of results they would like returned to them. Responses indicate a diversity of attitudes toward the return of incidental findings and a diversity of justifications for those attitudes. The majority of participants also described an imperative to include the patient in deciding which results to return rather than having universal, predetermined rules governing results disclosure. The results demonstrate the importance of a patient centered-approach to returning incidental findings.
AB - This article characterizes the opinions of patients and family members of patients undergoing clinical genomic-based testing regarding the return of incidental findings from these tests. Over sixteen months, we conducted 55 in-depth interviews with individuals to explore their preferences regarding which types of results they would like returned to them. Responses indicate a diversity of attitudes toward the return of incidental findings and a diversity of justifications for those attitudes. The majority of participants also described an imperative to include the patient in deciding which results to return rather than having universal, predetermined rules governing results disclosure. The results demonstrate the importance of a patient centered-approach to returning incidental findings.
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U2 - 10.1016/j.atg.2015.02.005
DO - 10.1016/j.atg.2015.02.005
M3 - Article
C2 - 26937348
AN - SCOPUS:84939978640
SN - 2212-0661
VL - 4
SP - 38
EP - 43
JO - Applied and Translational Genomics
JF - Applied and Translational Genomics
ER -