TY - JOUR
T1 - PCNA, the Maestro of the Replication Fork
AU - Moldovan, George Lucian
AU - Pfander, Boris
AU - Jentsch, Stefan
N1 - Funding Information:
We thank S. Bergink, H. Alwan, M. Sacher, G. Karras, M. Kalocay, and D. Siepe for comments on the manuscript and G. Karras for preparing Figure 1 . S.J. is funded by the Max Planck Society, Deutsche Forschungsgemeinschaft, Deutsche Krebshilfe, RUBICON ubiquitin network of the EU, and Fonds der chemischen Industrie. B.P. is supported by a Human Frontier Science Program fellowship.
PY - 2007/5/18
Y1 - 2007/5/18
N2 - Inheritance requires genome duplication, reproduction of chromatin and its epigenetic information, mechanisms to ensure genome integrity, and faithful transmission of the information to progeny. Proliferating cell nuclear antigen (PCNA)-a cofactor of DNA polymerases that encircles DNA-orchestrates several of these functions by recruiting crucial players to the replication fork. Remarkably, many factors that are involved in replication-linked processes interact with a particular face of PCNA and through the same interaction domain, indicating that these interactions do not occur simultaneously during replication. Switching of PCNA partners may be triggered by affinity-driven competition, phosphorylation, proteolysis, and modification of PCNA by ubiquitin and SUMO.
AB - Inheritance requires genome duplication, reproduction of chromatin and its epigenetic information, mechanisms to ensure genome integrity, and faithful transmission of the information to progeny. Proliferating cell nuclear antigen (PCNA)-a cofactor of DNA polymerases that encircles DNA-orchestrates several of these functions by recruiting crucial players to the replication fork. Remarkably, many factors that are involved in replication-linked processes interact with a particular face of PCNA and through the same interaction domain, indicating that these interactions do not occur simultaneously during replication. Switching of PCNA partners may be triggered by affinity-driven competition, phosphorylation, proteolysis, and modification of PCNA by ubiquitin and SUMO.
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U2 - 10.1016/j.cell.2007.05.003
DO - 10.1016/j.cell.2007.05.003
M3 - Review article
C2 - 17512402
AN - SCOPUS:34249066085
SN - 0092-8674
VL - 129
SP - 665
EP - 679
JO - Cell
JF - Cell
IS - 4
ER -