PCNA, the Maestro of the Replication Fork

George Lucian Moldovan; Boris Pfander; Stefan Jentsch

doi:10.1016/j.cell.2007.05.003

PCNA, the Maestro of the Replication Fork

George Lucian Moldovan
, Boris Pfander
, Stefan Jentsch

Research output: Contribution to journal › Review article › peer-review

1557 Scopus citations

Abstract

Inheritance requires genome duplication, reproduction of chromatin and its epigenetic information, mechanisms to ensure genome integrity, and faithful transmission of the information to progeny. Proliferating cell nuclear antigen (PCNA)-a cofactor of DNA polymerases that encircles DNA-orchestrates several of these functions by recruiting crucial players to the replication fork. Remarkably, many factors that are involved in replication-linked processes interact with a particular face of PCNA and through the same interaction domain, indicating that these interactions do not occur simultaneously during replication. Switching of PCNA partners may be triggered by affinity-driven competition, phosphorylation, proteolysis, and modification of PCNA by ubiquitin and SUMO.

Original language	English (US)
Pages (from-to)	665-679
Number of pages	15
Journal	Cell
Volume	129
Issue number	4
DOIs	https://doi.org/10.1016/j.cell.2007.05.003
State	Published - May 18 2007

All Science Journal Classification (ASJC) codes

General Biochemistry, Genetics and Molecular Biology

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10.1016/j.cell.2007.05.003

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title = "PCNA, the Maestro of the Replication Fork",

abstract = "Inheritance requires genome duplication, reproduction of chromatin and its epigenetic information, mechanisms to ensure genome integrity, and faithful transmission of the information to progeny. Proliferating cell nuclear antigen (PCNA)-a cofactor of DNA polymerases that encircles DNA-orchestrates several of these functions by recruiting crucial players to the replication fork. Remarkably, many factors that are involved in replication-linked processes interact with a particular face of PCNA and through the same interaction domain, indicating that these interactions do not occur simultaneously during replication. Switching of PCNA partners may be triggered by affinity-driven competition, phosphorylation, proteolysis, and modification of PCNA by ubiquitin and SUMO.",

author = "Moldovan, \{George Lucian\} and Boris Pfander and Stefan Jentsch",

note = "Funding Information: We thank S. Bergink, H. Alwan, M. Sacher, G. Karras, M. Kalocay, and D. Siepe for comments on the manuscript and G. Karras for preparing Figure 1 . S.J. is funded by the Max Planck Society, Deutsche Forschungsgemeinschaft, Deutsche Krebshilfe, RUBICON ubiquitin network of the EU, and Fonds der chemischen Industrie. B.P. is supported by a Human Frontier Science Program fellowship. ",

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doi = "10.1016/j.cell.2007.05.003",

language = "English (US)",

volume = "129",

pages = "665--679",

journal = "Cell",

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publisher = "Elsevier B.V.",

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T1 - PCNA, the Maestro of the Replication Fork

AU - Moldovan, George Lucian

AU - Pfander, Boris

AU - Jentsch, Stefan

N1 - Funding Information: We thank S. Bergink, H. Alwan, M. Sacher, G. Karras, M. Kalocay, and D. Siepe for comments on the manuscript and G. Karras for preparing Figure 1 . S.J. is funded by the Max Planck Society, Deutsche Forschungsgemeinschaft, Deutsche Krebshilfe, RUBICON ubiquitin network of the EU, and Fonds der chemischen Industrie. B.P. is supported by a Human Frontier Science Program fellowship.

PY - 2007/5/18

Y1 - 2007/5/18

N2 - Inheritance requires genome duplication, reproduction of chromatin and its epigenetic information, mechanisms to ensure genome integrity, and faithful transmission of the information to progeny. Proliferating cell nuclear antigen (PCNA)-a cofactor of DNA polymerases that encircles DNA-orchestrates several of these functions by recruiting crucial players to the replication fork. Remarkably, many factors that are involved in replication-linked processes interact with a particular face of PCNA and through the same interaction domain, indicating that these interactions do not occur simultaneously during replication. Switching of PCNA partners may be triggered by affinity-driven competition, phosphorylation, proteolysis, and modification of PCNA by ubiquitin and SUMO.

AB - Inheritance requires genome duplication, reproduction of chromatin and its epigenetic information, mechanisms to ensure genome integrity, and faithful transmission of the information to progeny. Proliferating cell nuclear antigen (PCNA)-a cofactor of DNA polymerases that encircles DNA-orchestrates several of these functions by recruiting crucial players to the replication fork. Remarkably, many factors that are involved in replication-linked processes interact with a particular face of PCNA and through the same interaction domain, indicating that these interactions do not occur simultaneously during replication. Switching of PCNA partners may be triggered by affinity-driven competition, phosphorylation, proteolysis, and modification of PCNA by ubiquitin and SUMO.

UR - https://www.scopus.com/pages/publications/34249066085

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U2 - 10.1016/j.cell.2007.05.003

DO - 10.1016/j.cell.2007.05.003

M3 - Review article

C2 - 17512402

AN - SCOPUS:34249066085

SN - 0092-8674

VL - 129

SP - 665

EP - 679

JO - Cell

JF - Cell

IS - 4

ER -

PCNA, the Maestro of the Replication Fork

Abstract

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