PCTR1 Enhances Repair and Bacterial Clearance in Skin Wounds

Brian E. Sansbury, Xiaofeng Li, Blenda Wong, Colin O. Riley, Ashley E. Shay, Robert Nshimiyimana, Nicos A. Petasis, Charles N. Serhan, Matthew Spite

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


Tissue injury elicits an inflammatory response that facilitates host defense. Resolution of inflammation promotes the transition to tissue repair and is governed, in part, by specialized pro-resolving mediators (SPM). The complete structures of a novel series of cysteinyl-SPM (cys-SPM) were recently elucidated, and proved to stimulate tissue regeneration in planaria and resolve acute inflammation in mice. Their functions in mammalian tissue repair are of interest. Here, nine structurally distinct cys-SPM were screened and PCTR1 uniquely enhanced human keratinocyte migration with efficacy similar to epidermal growth factor. In skin wounds of mice, PCTR1 accelerated closure. Wound infection increased PCTR1 that coincided with decreased bacterial burden. Addition of PCTR1 reduced wound bacteria levels and decreased inflammatory monocytes/macrophages, which was coupled with increased expression of genes involved in host defense and tissue repair. These results suggest that PCTR1 is a novel regulator of host defense and tissue repair, which could inform new approaches for therapeutic management of delayed tissue repair and infection.

Original languageEnglish (US)
Pages (from-to)1049-1063
Number of pages15
JournalAmerican Journal of Pathology
Issue number6
StatePublished - Jun 2021

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine


Dive into the research topics of 'PCTR1 Enhances Repair and Bacterial Clearance in Skin Wounds'. Together they form a unique fingerprint.

Cite this