Pd-Catalyzed 1,3-Alkenylarylation of Skipped Diene via Metal Migration

Lucas J. Chesley, Dhruba P. Poudel, Rishi R. Sapkota, Roshan K. Dhungana, Margaret G. Lakomy, Ramesh Giri

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


We disclose a palladium-catalyzed difunctionalization of skipped diene with alkenyl triflates and arylboronic acids to produce 1,3-alkenylarylated products. The reaction proceeded efficiently with Pd(acac)2 as a catalyst and CsF as a base for a wide range of electron-deficient and electron-rich arylboronic acids as well as oxygen-heterocyclic, sterically hindered, and complex natural product-derived alkenyl triflates bearing various functional groups. The reaction produced 3-aryl-5-alkenylcyclohexene derivatives with 1,3-syn-disubstituted stereochemistry.

Original languageEnglish (US)
Pages (from-to)19912-19916
Number of pages5
JournalACS Omega
Issue number22
StatePublished - Jun 6 2023

All Science Journal Classification (ASJC) codes

  • General Chemistry
  • General Chemical Engineering

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