PEDF: A multifaceted neurotrophic factor

Joyce Tombran-Tink; Colin J. Barnstable

doi:10.1038/nrn1176

PEDF: A multifaceted neurotrophic factor

Joyce Tombran-Tink, Colin J. Barnstable

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333 Scopus citations

Abstract

Pigment epithelium-derived factor (PEDF) is a potent and broadly acting neurotrophic factor that protects neurons in many regions of the central nervous system against insults such as glutamate excitotoxicity and oxidative damage. Since the crystal structure of PEDF was solved, its biological actions have begun to be mapped to specific structural domains. Here we discuss the structure and function of PEDF and the biochemical pathways it activates, and suggest ways in which this molecule might become a valuable therapeutic agent.

Original language	English (US)
Pages (from-to)	628-636
Number of pages	9
Journal	Nature Reviews Neuroscience
Volume	4
Issue number	8
DOIs	https://doi.org/10.1038/nrn1176
State	Published - Aug 2003

All Science Journal Classification (ASJC) codes

General Neuroscience

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10.1038/nrn1176

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PEDF: A multifaceted neurotrophic factor

Abstract

All Science Journal Classification (ASJC) codes

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